Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 302711..303224 Replicon chromosome
Accession NZ_AP017572
Organism Rickettsia japonica strain DT-1

Toxin (Protein)


Gene name yoeB Uniprot ID G4KME1
Locus tag BZI87_RS01685 Protein ID WP_014120591.1
Coordinates 302964..303224 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F3RGJ3
Locus tag BZI87_RS01680 Protein ID WP_014013992.1
Coordinates 302711..302953 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZI87_RS01660 297738..299507 - 1770 WP_024704469.1 ABC transporter ATP-binding protein/permease -
BZI87_RS01665 299688..299957 + 270 WP_014013989.1 DUF2671 domain-containing protein -
BZI87_RS01670 300112..301482 + 1371 WP_014120588.1 cytochrome ubiquinol oxidase subunit I -
BZI87_RS01675 301490..302509 + 1020 WP_014120589.1 cytochrome d ubiquinol oxidase subunit II -
BZI87_RS01680 302711..302953 + 243 WP_014013992.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BZI87_RS01685 302964..303224 + 261 WP_014120591.1 Txe/YoeB family addiction module toxin Toxin
BZI87_RS01690 303217..304065 + 849 WP_014120592.1 glycosyltransferase family 2 protein -
BZI87_RS01695 304142..305380 + 1239 WP_014120593.1 insulinase family protein -
BZI87_RS01700 305534..306244 + 711 WP_014120594.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
BZI87_RS01710 306473..308059 + 1587 WP_014120595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10254.07 Da        Isoelectric Point: 9.8788

>T31162 WP_014120591.1 NZ_AP017572:302964-303224 [Rickettsia japonica]
MYIIRYTTQAQKDAKKIVQAGLKNKVEVLLNIVSTDPWKIYPPYEKLVGDFSGCYSRRINIQHRLVCEVYKQEKVVKILR
MYTHYE

Download         Length: 261 bp

>T31162 NZ_AP017572:302964-303224 [Rickettsia japonica]
ATGTATATAATTCGTTATACTACACAAGCACAAAAAGATGCTAAGAAAATAGTGCAAGCCGGTTTAAAGAATAAAGTAGA
AGTTTTATTAAACATAGTTAGTACTGATCCTTGGAAAATTTACCCTCCATATGAAAAGCTCGTTGGTGACTTTAGCGGTT
GTTATTCAAGAAGAATTAATATTCAACATAGGTTGGTTTGTGAAGTTTACAAACAAGAAAAAGTTGTAAAAATTCTTAGA
ATGTATACGCATTATGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9405.83 Da        Isoelectric Point: 7.1617

>AT31162 WP_014013992.1 NZ_AP017572:302711-302953 [Rickettsia japonica]
MEIYNTSEARSKLYKLIDYVSDVHKPVYIKGKRNNVVIISEEDYRNMEETLYLLSIPNMHKSLIEGRAEPIAKCSDKLNW

Download         Length: 243 bp

>AT31162 NZ_AP017572:302711-302953 [Rickettsia japonica]
ATGGAAATATATAATACAAGCGAAGCAAGAAGTAAGCTTTATAAACTTATAGATTATGTTTCTGATGTACACAAACCTGT
TTATATTAAAGGTAAAAGAAATAATGTAGTTATAATTTCAGAAGAAGATTATCGTAATATGGAAGAAACTTTATATTTAT
TATCTATTCCAAATATGCATAAGTCTCTAATTGAAGGACGAGCAGAGCCTATAGCAAAGTGTAGCGATAAATTAAATTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3B7DC01

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3RGJ3

References