Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3547208..3547815 Replicon chromosome
Accession NZ_AP017560
Organism Pseudanabaena sp. ABRG5-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ABRG53_RS16125 Protein ID WP_126387863.1
Coordinates 3547531..3547815 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ABRG53_RS16120 Protein ID WP_126387861.1
Coordinates 3547208..3547513 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABRG53_RS16095 3542483..3543301 - 819 WP_126387851.1 mechanosensitive ion channel family protein -
ABRG53_RS16100 3543707..3544123 + 417 WP_126387853.1 hypothetical protein -
ABRG53_RS16105 3544317..3544742 + 426 WP_126387855.1 large conductance mechanosensitive channel protein MscL -
ABRG53_RS16110 3544744..3545829 + 1086 WP_126387857.1 hypothetical protein -
ABRG53_RS16115 3545908..3547143 + 1236 WP_126387859.1 dihydroorotase -
ABRG53_RS16120 3547208..3547513 - 306 WP_126387861.1 HigA family addiction module antidote protein Antitoxin
ABRG53_RS16125 3547531..3547815 - 285 WP_126387863.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABRG53_RS16130 3547962..3550757 + 2796 WP_126387865.1 DEAD/DEAH box helicase family protein -
ABRG53_RS16135 3550922..3551356 + 435 WP_126387867.1 GxxExxY protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(15-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-70)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11089.72 Da        Isoelectric Point: 9.6250

>T31154 WP_126387863.1 NZ_AP017560:c3547815-3547531 [Pseudanabaena sp. ABRG5-3]
VIIRFKSRETKLIFDGFISRQYPTDIQKTALRKLLVLDAATSINDLRIPPANRLEKLIGDRQGQYSIRINNQWRICFVWT
EQNNADQVEIVDYH

Download         Length: 285 bp

>T31154 NZ_AP017560:c3547815-3547531 [Pseudanabaena sp. ABRG5-3]
GTGATCATACGTTTTAAGTCTAGAGAGACAAAGCTGATCTTTGATGGCTTTATATCTCGCCAATACCCAACTGATATTCA
AAAAACTGCCTTGAGAAAGCTTTTGGTTTTAGATGCAGCTACATCAATCAATGATTTACGAATTCCACCAGCAAATCGAC
TAGAAAAATTGATTGGCGATCGCCAAGGTCAATATAGTATCCGTATCAACAATCAATGGCGGATTTGCTTTGTTTGGACA
GAGCAAAATAATGCGGATCAAGTTGAAATCGTGGATTACCACTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11610.21 Da        Isoelectric Point: 6.4658

>AT31154 WP_126387861.1 NZ_AP017560:c3547513-3547208 [Pseudanabaena sp. ABRG5-3]
MENQRLPNIHPGEILLLEFLEPLEITPYRLSKDIGVAQTRISEILAEKRSITADTALRLARYFGNSAQFWLNLQTAYDLR
QAQEKNADIYKHIPQLATSNN

Download         Length: 306 bp

>AT31154 NZ_AP017560:c3547513-3547208 [Pseudanabaena sp. ABRG5-3]
ATGGAAAATCAGCGTCTACCGAACATTCACCCCGGAGAGATTCTTCTATTAGAATTCCTCGAACCTCTAGAAATTACTCC
CTATCGATTAAGTAAAGATATTGGAGTTGCTCAAACACGCATTAGTGAGATATTGGCTGAAAAACGTAGCATTACCGCAG
ATACTGCTTTACGTTTAGCACGTTATTTTGGTAATAGCGCTCAGTTCTGGTTAAATTTACAGACAGCCTACGATTTGCGA
CAAGCACAAGAAAAGAATGCTGATATCTATAAGCATATTCCTCAACTTGCGACCAGCAATAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References