Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3903820..3904547 Replicon chromosome
Accession NZ_AP017469
Organism Hafnia sp. CBA7124

Toxin (Protein)


Gene name higB Uniprot ID A0A377PNS5
Locus tag CPY98_RS17795 Protein ID WP_043489169.1
Coordinates 3903820..3904131 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A377PPD5
Locus tag CPY98_RS17800 Protein ID WP_043489166.1
Coordinates 3904128..3904547 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPY98_RS17785 3901318..3902229 - 912 WP_043489174.1 transcriptional regulator FeaR -
CPY98_RS17790 3902365..3903465 - 1101 WP_046448979.1 DUF1615 domain-containing protein -
CPY98_RS17795 3903820..3904131 + 312 WP_043489169.1 type II toxin-antitoxin system HigB family toxin Toxin
CPY98_RS17800 3904128..3904547 + 420 WP_043489166.1 helix-turn-helix domain-containing protein Antitoxin
CPY98_RS17805 3904632..3905315 - 684 WP_096388531.1 hypothetical protein -
CPY98_RS17810 3905308..3906342 - 1035 WP_038503035.1 StbA family protein -
CPY98_RS17820 3907016..3907798 - 783 WP_043489162.1 crotonobetainyl-CoA hydratase -
CPY98_RS17825 3907813..3909384 - 1572 WP_096388532.1 crotonobetaine/carnitine-CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12468.25 Da        Isoelectric Point: 9.7852

>T31144 WP_043489169.1 NZ_AP017469:3903820-3904131 [Hafnia sp. CBA7124]
MHIISRDPFEDAARKYPNDAASLIAAYRLLKENEFESPAELRKLFPNLDNFKYRNKWWVINIGGNNLRMISYINFVNQRF
YVKHIVTHAEYDKLTRQYREIKE

Download         Length: 312 bp

>T31144 NZ_AP017469:3903820-3904131 [Hafnia sp. CBA7124]
ATGCACATCATATCTAGGGATCCGTTTGAAGACGCCGCGCGAAAATACCCAAACGATGCCGCATCTCTCATCGCAGCATA
CCGATTGCTTAAAGAGAATGAATTTGAAAGTCCTGCAGAATTACGCAAACTGTTTCCTAACCTCGATAACTTCAAATATA
GGAACAAGTGGTGGGTAATCAACATTGGTGGCAACAATCTGCGGATGATTTCCTACATCAACTTTGTAAACCAGCGCTTT
TACGTCAAACACATCGTCACCCACGCAGAGTATGACAAGCTAACGAGGCAGTACCGGGAGATAAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15474.70 Da        Isoelectric Point: 4.5542

>AT31144 WP_043489166.1 NZ_AP017469:3904128-3904547 [Hafnia sp. CBA7124]
MILEPTKALEAAKVLADAVPFLGGNTSEEAYRDALAMVDYLIEHDDESPLIDFLALKIAEYEDNNERFKAFNQAVTDMPT
GVAALRVLIEQHQLSYSDLASEIGSKSLVSMILSGKRSLTIEHIKALSKRFNVRPDLFF

Download         Length: 420 bp

>AT31144 NZ_AP017469:3904128-3904547 [Hafnia sp. CBA7124]
ATGATTTTAGAACCGACCAAAGCGCTAGAGGCCGCAAAAGTATTGGCAGATGCCGTGCCTTTTTTAGGCGGCAATACTTC
TGAGGAGGCCTATCGCGATGCGCTCGCTATGGTTGATTATCTTATCGAGCACGATGACGAAAGCCCGCTAATAGATTTTC
TAGCGTTAAAAATTGCTGAATATGAAGATAACAATGAGCGATTTAAAGCCTTCAATCAGGCCGTGACTGATATGCCTACT
GGCGTGGCCGCGCTACGGGTTCTTATCGAACAACATCAGCTTTCCTACTCAGATTTAGCCTCAGAAATTGGTTCAAAAAG
CCTCGTCAGCATGATTTTATCCGGCAAACGCTCATTAACCATTGAGCATATCAAAGCACTCTCAAAGCGCTTTAACGTTA
GACCAGACCTGTTTTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377PNS5

Antitoxin

Source ID Structure
AlphaFold DB A0A377PPD5

References