Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 484329..484827 Replicon chromosome
Accession NZ_AP017469
Organism Hafnia sp. CBA7124

Toxin (Protein)


Gene name yoeB Uniprot ID A0A097QY90
Locus tag CPY98_RS02220 Protein ID WP_025798702.1
Coordinates 484329..484583 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A097QYE6
Locus tag CPY98_RS02225 Protein ID WP_025798704.1
Coordinates 484576..484827 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPY98_RS02190 479940..480473 + 534 WP_096388704.1 SprT family zinc-dependent metalloprotease -
CPY98_RS02195 480603..481313 + 711 WP_043490630.1 deoxyribonuclease I -
CPY98_RS02200 481436..482167 + 732 WP_096386194.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
CPY98_RS02205 482177..483130 + 954 WP_040046342.1 glutathione synthase -
CPY98_RS02210 483338..483901 + 564 WP_043490633.1 YqgE/AlgH family protein -
CPY98_RS02215 483901..484323 + 423 WP_046458214.1 Holliday junction resolvase RuvX -
CPY98_RS02220 484329..484583 - 255 WP_025798702.1 Txe/YoeB family addiction module toxin Toxin
CPY98_RS02225 484576..484827 - 252 WP_025798704.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CPY98_RS02230 484892..485908 - 1017 WP_096386197.1 type IV pilus twitching motility protein PilT -
CPY98_RS02235 485931..486644 + 714 WP_096386199.1 YggS family pyridoxal phosphate-dependent enzyme -
CPY98_RS02240 486718..487272 + 555 WP_025798710.1 YggT family protein -
CPY98_RS02245 487278..487580 + 303 WP_025798712.1 YggU family protein -
CPY98_RS02250 487634..488227 + 594 WP_043490641.1 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase -
CPY98_RS02255 488220..489350 + 1131 WP_046359444.1 radical SAM family heme chaperone HemW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10489.99 Da        Isoelectric Point: 8.8753

>T31132 WP_025798702.1 NZ_AP017469:c484583-484329 [Hafnia sp. CBA7124]
MNKFFTDESWADYVFWQENDKRFIKRINELIKEIERAPFTGIGKPEPLKHHLSGYWSRRINEEHRLIYRVEQDRMIILSC
RYHY

Download         Length: 255 bp

>T31132 NZ_AP017469:c484583-484329 [Hafnia sp. CBA7124]
ATGAATAAATTCTTCACGGATGAGTCTTGGGCCGATTATGTTTTCTGGCAGGAAAATGACAAACGTTTTATTAAACGTAT
CAATGAATTGATTAAAGAAATTGAAAGGGCCCCATTCACAGGAATTGGCAAACCAGAGCCTTTAAAACATCATCTATCGG
GTTATTGGTCACGCAGAATTAATGAAGAACACCGGCTCATTTATCGGGTAGAACAAGACAGGATGATCATCCTGTCTTGC
CGCTATCATTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9183.54 Da        Isoelectric Point: 5.7782

>AT31132 WP_025798704.1 NZ_AP017469:c484827-484576 [Hafnia sp. CBA7124]
MRNITYSAARATLASVMDQTIQDCTPILITRQNGEDCVLMSSKEYSSLMETAYLMRSPSNAEHLLKSLAQASAKALEKKV
LDE

Download         Length: 252 bp

>AT31132 NZ_AP017469:c484827-484576 [Hafnia sp. CBA7124]
ATGCGCAATATCACCTACTCAGCGGCTCGAGCCACTTTAGCCTCAGTCATGGATCAAACGATTCAGGACTGCACGCCCAT
ACTTATCACCCGTCAAAATGGTGAAGACTGCGTTTTAATGTCTAGCAAAGAGTATTCCAGCCTCATGGAAACCGCTTATT
TAATGCGCTCGCCCTCGAATGCTGAACACCTGCTTAAATCATTGGCACAAGCTAGCGCCAAGGCTCTAGAAAAGAAGGTG
CTGGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QY90

Antitoxin

Source ID Structure
AlphaFold DB A0A097QYE6

References