31119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2554231..2554748 Replicon chromosome
Accession NZ_AP017377
Organism Staphylococcus aureus strain OC8

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ATE38_RS13425 Protein ID WP_000113262.1
Coordinates 2554231..2554497 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ATE38_RS13430 Protein ID WP_000584499.1
Coordinates 2554497..2554748 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE38_RS13395 2549657..2550193 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
ATE38_RS13400 2550426..2551250 - 825 WP_000572040.1 formate/nitrite transporter family protein -
ATE38_RS13405 2551467..2551649 - 183 WP_000230294.1 hypothetical protein -
ATE38_RS13410 2551733..2552200 - 468 WP_000153344.1 SRPBCC domain-containing protein -
ATE38_RS13415 2552386..2553936 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ATE38_RS13420 2554125..2554196 - 72 Protein_2496 hypothetical protein -
ATE38_RS13425 2554231..2554497 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ATE38_RS13430 2554497..2554748 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ATE38_RS13435 2554913..2555014 - 102 WP_001791744.1 hypothetical protein -
ATE38_RS13440 2555021..2555620 - 600 WP_000162813.1 DsbA family protein -
ATE38_RS13445 2555639..2556001 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ATE38_RS13450 2556256..2557506 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
ATE38_RS13455 2557603..2558334 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
ATE38_RS13460 2558331..2559050 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T31119 WP_000113262.1 NZ_AP017377:c2554497-2554231 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T31119 NZ_AP017377:c2554497-2554231 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT31119 WP_000584499.1 NZ_AP017377:c2554748-2554497 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT31119 NZ_AP017377:c2554748-2554497 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References