Detailed information of TA system TA031112

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2113778..2114085
• Replicon: chromosome
• Accession: NZ_AP017377
• Organism: Staphylococcus aureus strain OC8

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ATE38_RS10995
• Protein ID: WP_011447039.1
• Coordinates: 2113909..2114085 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2113778..2113917 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATE38_RS10935	2109344..2109523	+	180	WP_000669791.1	hypothetical protein	-
ATE38_RS10945	2109834..2110094	+	261	WP_001791826.1	hypothetical protein	-
ATE38_RS10950	2110147..2110497	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
ATE38_RS10955	2111008..2111343	-	336	Protein_2033	SH3 domain-containing protein	-
ATE38_RS10975	2111994..2112485	-	492	WP_000920038.1	staphylokinase	-
ATE38_RS10980	2112676..2113431	-	756	WP_000861038.1	CHAP domain-containing protein	-
ATE38_RS10985	2113443..2113697	-	255	WP_000611508.1	phage holin	-
ATE38_RS10990	2113749..2113856	+	108	WP_031762631.1	hypothetical protein	-
-	2113778..2113917	+	140	NuclAT_0	-	Antitoxin
-	2113778..2113917	+	140	NuclAT_0	-	Antitoxin
-	2113778..2113917	+	140	NuclAT_0	-	Antitoxin
-	2113778..2113917	+	140	NuclAT_0	-	Antitoxin
ATE38_RS10995	2113909..2114085	-	177	WP_011447039.1	putative holin-like toxin	Toxin
ATE38_RS11000	2114194..2114967	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
ATE38_RS11005	2115340..2115714	-	375	WP_000340977.1	hypothetical protein	-
ATE38_RS11010	2115770..2116057	-	288	WP_001262621.1	hypothetical protein	-
ATE38_RS11015	2116103..2116255	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2110147..2166018	55871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T31112 WP_011447039.1 NZ_AP017377:c2114085-2113909 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T31112 NZ_AP017377:c2114085-2113909 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT31112 NZ_AP017377:2113778-2113917 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin