Detailed information of TA system TA031108

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1250680..1251259
• Replicon: chromosome
• Accession: NZ_AP017377
• Organism: Staphylococcus aureus strain OC8

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: ATE38_RS06350
• Protein ID: WP_001025401.1
• Coordinates: 1250680..1250925 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1250894..1251259 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATE38_RS06315	1246598..1247221	+	624	WP_001166484.1	hypothetical protein	-
ATE38_RS06320	1247367..1247549	-	183	WP_000705240.1	hypothetical protein	-
ATE38_RS06325	1247645..1248565	-	921	WP_000348133.1	3'-5' exoribonuclease	-
ATE38_RS06330	1248581..1249195	-	615	WP_000801423.1	XRE family transcriptional regulator	-
ATE38_RS06335	1249367..1249594	+	228	WP_001030311.1	hypothetical protein	-
ATE38_RS06340	1249620..1250396	+	777	WP_001148559.1	phage antirepressor	-
ATE38_RS06345	1250412..1250630	+	219	WP_001001383.1	hypothetical protein	-
ATE38_RS06350	1250680..1250925	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
ATE38_RS06355	1250894..1251259	-	366	WP_001128433.1	hypothetical protein	Antitoxin
ATE38_RS06360	1251314..1251529	+	216	WP_001097552.1	hypothetical protein	-
ATE38_RS06365	1251556..1251819	+	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
ATE38_RS06370	1251832..1251993	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
ATE38_RS06375	1252072..1252395	+	324	WP_000174994.1	hypothetical protein	-
ATE38_RS06380	1252410..1252772	+	363	WP_000985976.1	hypothetical protein	-
ATE38_RS06385	1252769..1253935	+	1167	WP_000762548.1	DUF2800 domain-containing protein	-
ATE38_RS06390	1253961..1254518	+	558	WP_000645048.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1242276..1294255	51979

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T31108 WP_001025401.1 NZ_AP017377:1250680-1250925 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T31108 NZ_AP017377:1250680-1250925 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT31108 NZ_AP017377:c1251259-1250894 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin