Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 20797..21401 Replicon plasmid plasmid1 DNA
Accession NZ_AP017376
Organism Stanieria sp. NIES-3757

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag STA3757_RS24020 Protein ID WP_096388255.1
Coordinates 21108..21401 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag STA3757_RS24015 Protein ID WP_096388253.1
Coordinates 20797..21096 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STA3757_RS23985 15981..16568 + 588 WP_096388247.1 Uma2 family endonuclease -
STA3757_RS23990 16577..17449 - 873 WP_096388249.1 hypothetical protein -
STA3757_RS23995 17790..18113 - 324 WP_041620505.1 helix-turn-helix domain-containing protein -
STA3757_RS24000 18128..18409 - 282 WP_096388425.1 type II toxin-antitoxin system RelE/ParE family toxin -
STA3757_RS24005 18435..19495 - 1061 Protein_25 IS630 family transposase -
STA3757_RS24010 19818..20774 + 957 WP_096388251.1 site-specific integrase -
STA3757_RS24015 20797..21096 - 300 WP_096388253.1 HigA family addiction module antidote protein Antitoxin
STA3757_RS24020 21108..21401 - 294 WP_096388255.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
STA3757_RS24025 21463..23697 - 2235 WP_096388257.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..143540 143540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-98)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11402.99 Da        Isoelectric Point: 9.4837

>T31102 WP_096388255.1 NZ_AP017376:c21401-21108 [Stanieria sp. NIES-3757]
MIINYKHQGVKDIFNGDDTKYARKVCPQNLWKIARRKLDQLDFAASLNDLRSPPKNRLEALKGSREGQHSIRINDQYRIC
FIWSNDGIKDVEIVDYH

Download         Length: 294 bp

>T31102 NZ_AP017376:c21401-21108 [Stanieria sp. NIES-3757]
ATGATAATTAATTATAAACACCAAGGAGTAAAAGATATTTTTAATGGAGATGATACAAAGTATGCGCGGAAAGTTTGCCC
TCAAAACCTATGGAAAATAGCGAGACGAAAGCTCGACCAATTAGATTTTGCAGCTAGCTTAAATGATTTGCGTTCTCCAC
CTAAGAATCGATTAGAGGCTTTAAAAGGCAGCCGAGAAGGACAACACAGTATTCGCATTAACGACCAGTATAGAATTTGT
TTTATCTGGTCAAACGATGGTATTAAAGATGTTGAAATTGTAGATTATCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11353.07 Da        Isoelectric Point: 8.4811

>AT31102 WP_096388253.1 NZ_AP017376:c21096-20797 [Stanieria sp. NIES-3757]
MVNIPTNRPPTSPGEMLKEEFLEPMGLTQQQLADGIGVSYQRINELINGKRGITTSTALRLAKYFNTSPDFWLNMQRANE
LYRVMQKERGEIEKIQPIV

Download         Length: 300 bp

>AT31102 NZ_AP017376:c21096-20797 [Stanieria sp. NIES-3757]
ATGGTTAATATCCCAACTAATAGACCCCCTACCAGTCCTGGTGAGATGTTGAAAGAAGAATTTTTAGAACCAATGGGATT
GACCCAGCAACAACTCGCTGATGGAATTGGAGTAAGCTATCAAAGGATTAACGAACTGATTAATGGTAAGAGGGGAATTA
CAACCAGTACTGCTTTAAGATTAGCCAAATATTTTAATACATCTCCTGATTTCTGGTTAAATATGCAAAGGGCGAACGAG
CTATATCGGGTCATGCAAAAAGAAAGAGGGGAGATTGAAAAGATTCAACCGATCGTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References