Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2545967..2546151 Replicon chromosome
Accession NZ_AP017320
Organism Staphylococcus aureus strain MI

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag SAMI_RS13080 Protein ID WP_000482652.1
Coordinates 2546044..2546151 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2545967..2546027 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMI_RS13055 2541422..2541589 - 168 Protein_2480 hypothetical protein -
SAMI_RS13065 2541820..2543553 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
SAMI_RS13070 2543578..2545341 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2545967..2546027 + 61 - - Antitoxin
SAMI_RS13080 2546044..2546151 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
SAMI_RS13085 2546285..2546671 - 387 WP_000779360.1 flippase GtxA -
SAMI_RS13090 2546939..2548081 + 1143 WP_001176863.1 glycerate kinase -
SAMI_RS13095 2548141..2548800 + 660 Protein_2486 hypothetical protein -
SAMI_RS13100 2548982..2550193 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAMI_RS13105 2550316..2550789 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T31086 WP_000482652.1 NZ_AP017320:c2546151-2546044 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T31086 NZ_AP017320:c2546151-2546044 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT31086 NZ_AP017320:2545967-2546027 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References