Detailed information of TA system TA031078

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2086840..2087147
• Replicon: chromosome
• Accession: NZ_AP017320
• Organism: Staphylococcus aureus strain MI

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAMI_RS15375
• Protein ID: WP_011447039.1
• Coordinates: 2086971..2087147 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2086840..2086979 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAMI_RS10580	2082180..2082440	+	261	WP_001791826.1	hypothetical protein	-
SAMI_RS10585	2082493..2082843	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAMI_RS10590	2083527..2083976	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAMI_RS15700	2084071..2084406	-	336	Protein_2004	SH3 domain-containing protein	-
SAMI_RS10600	2085056..2085547	-	492	WP_000919350.1	staphylokinase	-
SAMI_RS10605	2085738..2086493	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAMI_RS10610	2086505..2086759	-	255	WP_000611512.1	phage holin	-
SAMI_RS10615	2086811..2086918	+	108	WP_001791821.1	hypothetical protein	-
-	2086840..2086979	+	140	NuclAT_0	-	Antitoxin
-	2086840..2086979	+	140	NuclAT_0	-	Antitoxin
-	2086840..2086979	+	140	NuclAT_0	-	Antitoxin
-	2086840..2086979	+	140	NuclAT_0	-	Antitoxin
SAMI_RS15375	2086971..2087147	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAMI_RS10620	2087297..2087593	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAMI_RS10625	2087651..2087938	-	288	WP_001040254.1	hypothetical protein	-
SAMI_RS10630	2087985..2088137	-	153	WP_001153681.1	hypothetical protein	-
SAMI_RS10635	2088127..2091912	-	3786	WP_000582180.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2082493..2136787	54294

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T31078 WP_011447039.1 NZ_AP017320:c2087147-2086971 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T31078 NZ_AP017320:c2087147-2086971 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT31078 NZ_AP017320:2086840-2086979 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin