Detailed information of TA system TA031072

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1599518..1600097
• Replicon: chromosome
• Accession: NZ_AP017320
• Organism: Staphylococcus aureus strain MI

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAMI_RS07935
• Protein ID: WP_001025401.1
• Coordinates: 1599852..1600097 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1599518..1599883 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAMI_RS07895	1596259..1596816	-	558	WP_000645045.1	DUF2815 family protein	-
SAMI_RS07900	1596842..1598008	-	1167	WP_000762546.1	DUF2800 domain-containing protein	-
SAMI_RS07905	1598005..1598367	-	363	WP_000985976.1	hypothetical protein	-
SAMI_RS07910	1598382..1598705	-	324	WP_000174994.1	hypothetical protein	-
SAMI_RS07915	1598784..1598945	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
SAMI_RS07920	1598958..1599221	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
SAMI_RS07925	1599248..1599463	-	216	WP_001097552.1	hypothetical protein	-
SAMI_RS07930	1599518..1599883	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAMI_RS07935	1599852..1600097	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAMI_RS07940	1600164..1600544	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
SAMI_RS07945	1600531..1600728	-	198	WP_001148860.1	hypothetical protein	-
SAMI_RS07950	1600798..1601010	+	213	WP_000362643.1	hypothetical protein	-
SAMI_RS15795	1601051..1601200	-	150	WP_000771849.1	hypothetical protein	-
SAMI_RS07955	1601215..1601658	-	444	WP_000435357.1	hypothetical protein	-
SAMI_RS07960	1601706..1601918	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
SAMI_RS07965	1602070..1602801	+	732	WP_000511090.1	XRE family transcriptional regulator	-
SAMI_RS07970	1602872..1603054	+	183	WP_000705240.1	hypothetical protein	-
SAMI_RS07975	1603091..1603237	+	147	WP_001794606.1	hypothetical protein	-
SAMI_RS07980	1603234..1603848	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	1556161..1629541	73380

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T31072 WP_001025401.1 NZ_AP017320:c1600097-1599852 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T31072 NZ_AP017320:c1600097-1599852 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT31072 NZ_AP017320:1599518-1599883 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin