Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2455056..2455663 Replicon chromosome
Accession NZ_AP014946
Organism Variibacter gotjawalensis strain GJW-30

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GJW30_RS11915 Protein ID WP_096355573.1
Coordinates 2455379..2455663 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GJW30_RS11910 Protein ID WP_096355571.1
Coordinates 2455056..2455358 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJW30_RS11895 2452077..2453156 - 1080 WP_096355564.1 NAD(P)-dependent alcohol dehydrogenase -
GJW30_RS11900 2453201..2453854 - 654 WP_096355566.1 TetR/AcrR family transcriptional regulator -
GJW30_RS11905 2453910..2454764 - 855 WP_096355569.1 crotonase/enoyl-CoA hydratase family protein -
GJW30_RS11910 2455056..2455358 - 303 WP_096355571.1 HigA family addiction module antidote protein Antitoxin
GJW30_RS11915 2455379..2455663 - 285 WP_096355573.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJW30_RS11920 2455730..2456617 - 888 WP_096355575.1 hydrogen peroxide-inducible genes activator -
GJW30_RS11925 2456819..2458987 + 2169 WP_096355577.1 catalase/peroxidase HPI -
GJW30_RS11930 2459230..2460411 - 1182 WP_157746744.1 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-82)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10571.08 Da        Isoelectric Point: 9.8027

>T31034 WP_096355573.1 NZ_AP014946:c2455663-2455379 [Variibacter gotjawalensis]
VILNFKDRLTEAAFNGTAVKGFPAALLGVTRRKLRYLHAAHVLDDLRAPPGNRLEALTGDRKGQHSIRVNDQFRICFVWT
PNGPTEVEFVDYHA

Download         Length: 285 bp

>T31034 NZ_AP014946:c2455663-2455379 [Variibacter gotjawalensis]
GTGATCCTGAATTTCAAAGATCGGCTGACCGAGGCGGCGTTCAATGGAACCGCTGTTAAGGGATTTCCGGCCGCCCTGCT
CGGTGTGACGCGGCGAAAGCTGAGATACTTGCATGCAGCCCATGTGCTGGACGACCTGCGCGCGCCGCCCGGCAACCGGC
TCGAAGCGCTGACGGGCGATCGCAAAGGTCAACACTCGATCCGCGTCAACGATCAATTTCGGATCTGCTTCGTCTGGACG
CCGAACGGGCCCACCGAGGTCGAATTCGTCGATTATCACGCGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10931.69 Da        Isoelectric Point: 8.0167

>AT31034 WP_096355571.1 NZ_AP014946:c2455358-2455056 [Variibacter gotjawalensis]
MAKTLPPMHPGEVLREEFLIPLNMSPGALARACDVPRTRIERLANEQTPVTADTALRLAKALGTSAELWLNLQADYDLQV
TRAKIGRDLKAIESVNPKAA

Download         Length: 303 bp

>AT31034 NZ_AP014946:c2455358-2455056 [Variibacter gotjawalensis]
ATGGCCAAGACACTGCCGCCAATGCATCCCGGAGAGGTTCTCCGCGAAGAGTTTCTCATCCCACTCAATATGTCGCCGGG
CGCGCTCGCACGTGCCTGCGATGTACCGCGTACGCGGATCGAGCGATTGGCGAATGAGCAGACGCCCGTTACGGCCGATA
CGGCACTGCGTCTCGCGAAAGCGTTGGGTACGAGCGCCGAATTGTGGCTGAACCTGCAGGCGGACTACGATCTTCAAGTC
ACGCGCGCAAAGATCGGGCGCGATCTCAAGGCCATCGAGAGCGTCAATCCGAAGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References