31024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2435238..2435755 Replicon chromosome
Accession NZ_AP014942
Organism Staphylococcus aureus strain FDA209P

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SAFDA_RS12380 Protein ID WP_000113262.1
Coordinates 2435238..2435504 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAFDA_RS12385 Protein ID WP_000584499.1
Coordinates 2435504..2435755 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAFDA_RS12355 2430657..2431193 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
SAFDA_RS12360 2431427..2432251 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAFDA_RS12365 2432468..2432650 - 183 WP_000079142.1 hypothetical protein -
SAFDA_RS12370 2432737..2433204 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SAFDA_RS12375 2433390..2434943 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAFDA_RS14990 2435132..2435203 - 72 Protein_2331 hypothetical protein -
SAFDA_RS12380 2435238..2435504 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SAFDA_RS12385 2435504..2435755 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAFDA_RS12390 2435920..2436021 - 102 WP_031774922.1 hypothetical protein -
SAFDA_RS12395 2436028..2436627 - 600 WP_000162813.1 DsbA family protein -
SAFDA_RS12400 2436646..2437008 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAFDA_RS12405 2437263..2438513 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
SAFDA_RS12410 2438592..2439911 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2438592..2439911 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T31024 WP_000113262.1 NZ_AP014942:c2435504-2435238 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T31024 NZ_AP014942:c2435504-2435238 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT31024 WP_000584499.1 NZ_AP014942:c2435755-2435504 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT31024 NZ_AP014942:c2435755-2435504 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References