Detailed information of TA system TA031019

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2002496..2002803
• Replicon: chromosome
• Accession: NZ_AP014942
• Organism: Staphylococcus aureus strain FDA209P

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: SAFDA_RS14645
• Protein ID: WP_072353918.1
• Coordinates: 2002627..2002803 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2002496..2002635 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAFDA_RS09955	1998062..1998241	+	180	WP_000669789.1	hypothetical protein	-
SAFDA_RS09965	1998552..1998812	+	261	WP_001791826.1	hypothetical protein	-
SAFDA_RS09970	1998865..1999215	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
SAFDA_RS14975	1999725..2000060	-	336	Protein_1877	SH3 domain-containing protein	-
SAFDA_RS09980	2000712..2001203	-	492	WP_000920041.1	staphylokinase	-
SAFDA_RS09985	2001394..2002149	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAFDA_RS09990	2002161..2002415	-	255	WP_000611512.1	phage holin	-
SAFDA_RS09995	2002467..2002574	+	108	WP_001791821.1	hypothetical protein	-
-	2002496..2002635	+	140	NuclAT_0	-	Antitoxin
-	2002496..2002635	+	140	NuclAT_0	-	Antitoxin
-	2002496..2002635	+	140	NuclAT_0	-	Antitoxin
-	2002496..2002635	+	140	NuclAT_0	-	Antitoxin
SAFDA_RS14645	2002627..2002803	-	177	WP_072353918.1	putative holin-like toxin	Toxin
SAFDA_RS10000	2002946..2003320	-	375	WP_000340977.1	hypothetical protein	-
SAFDA_RS10005	2003376..2003663	-	288	WP_001262620.1	hypothetical protein	-
SAFDA_RS10010	2003709..2003861	-	153	WP_001000058.1	hypothetical protein	-
SAFDA_RS10015	2003854..2007636	-	3783	WP_042727565.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1998865..2056496	57631

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T31019 WP_072353918.1 NZ_AP014942:c2002803-2002627 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T31019 NZ_AP014942:c2002803-2002627 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT31019 NZ_AP014942:2002496-2002635 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin