Detailed information of TA system TA031012

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2492536..2492720
• Replicon: chromosome
• Accession: NZ_AP014921
• Organism: Staphylococcus aureus strain JH4899

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: JSA_RS12995
• Protein ID: WP_000482650.1
• Coordinates: 2492613..2492720 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2492536..2492596 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSA_RS12970	2488066..2488233	-	168	WP_001790576.1	hypothetical protein	-
JSA_RS12980	2488464..2490197	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
JSA_RS12985	2490222..2491985	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	2492536..2492596	+	61	-	-	Antitoxin
JSA_RS12995	2492613..2492720	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
JSA_RS13000	2492853..2493239	-	387	WP_000779358.1	flippase GtxA	-
JSA_RS13005	2493507..2494649	+	1143	WP_001176862.1	glycerate kinase	-
JSA_RS13010	2494709..2495368	+	660	WP_000831298.1	membrane protein	-
JSA_RS13015	2495550..2496761	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JSA_RS13020	2496884..2497357	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T31012 WP_000482650.1 NZ_AP014921:c2492720-2492613 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T31012 NZ_AP014921:c2492720-2492613 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT31012 NZ_AP014921:2492536-2492596 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin