Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2467183..2467700 Replicon chromosome
Accession NZ_AP014921
Organism Staphylococcus aureus strain JH4899

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag JSA_RS12835 Protein ID WP_000113262.1
Coordinates 2467183..2467449 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag JSA_RS12840 Protein ID WP_000584499.1
Coordinates 2467449..2467700 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSA_RS12805 2462612..2463148 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
JSA_RS12810 2463381..2464205 - 825 WP_000572040.1 formate/nitrite transporter family protein -
JSA_RS12815 2464422..2464604 - 183 WP_000230294.1 hypothetical protein -
JSA_RS12820 2464688..2465155 - 468 WP_000153344.1 SRPBCC domain-containing protein -
JSA_RS12825 2465341..2466888 - 1548 WP_001551849.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JSA_RS12830 2467077..2467148 - 72 Protein_2377 hypothetical protein -
JSA_RS12835 2467183..2467449 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
JSA_RS12840 2467449..2467700 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JSA_RS12845 2467865..2467966 - 102 WP_001791744.1 hypothetical protein -
JSA_RS12850 2467973..2468572 - 600 WP_000162813.1 DsbA family protein -
JSA_RS12855 2468591..2468953 - 363 WP_000819843.1 DUF4467 domain-containing protein -
JSA_RS12860 2469209..2470459 + 1251 WP_001012226.1 FemA/FemB family glycyltransferase FmhA -
JSA_RS12865 2470556..2471287 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
JSA_RS12870 2471284..2472003 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T31011 WP_000113262.1 NZ_AP014921:c2467449-2467183 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T31011 NZ_AP014921:c2467449-2467183 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT31011 WP_000584499.1 NZ_AP014921:c2467700-2467449 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT31011 NZ_AP014921:c2467700-2467449 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References