Detailed information of TA system TA031010

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2201929..2202146
• Replicon: chromosome
• Accession: NZ_AP014921
• Organism: Staphylococcus aureus strain JH4899

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JSA_RS11420
• Protein ID: WP_001802298.1
• Coordinates: 2202042..2202146 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2201929..2201984 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSA_RS11400	2198132..2198797	-	666	WP_001024094.1	SDR family oxidoreductase	-
JSA_RS11405	2198949..2199269	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JSA_RS11410	2199271..2200251	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
JSA_RS11415	2200517..2201608	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2201929..2201984	+	56	-	-	Antitoxin
JSA_RS11420	2202042..2202146	-	105	WP_001802298.1	hypothetical protein	Toxin
JSA_RS14855	2202307..2202790	-	484	Protein_2111	recombinase family protein	-
JSA_RS11430	2202833..2203969	-	1137	WP_000115563.1	SAP domain-containing protein	-
JSA_RS11435	2204258..2204350	+	93	WP_001790138.1	hypothetical protein	-
JSA_RS11440	2205055..2205912	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
JSA_RS11445	2205980..2206762	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T31010 WP_001802298.1 NZ_AP014921:c2202146-2202042 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T31010 NZ_AP014921:c2202146-2202042 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT31010 NZ_AP014921:2201929-2201984 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin