Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 585682..586258 Replicon chromosome
Accession NZ_AP014879
Organism Sulfuricaulis limicola strain HA5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SCL_RS02905 Protein ID WP_096359833.1
Coordinates 585682..585960 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag SCL_RS02910 Protein ID WP_197702750.1
Coordinates 585974..586258 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCL_RS02885 581393..582352 - 960 WP_172425895.1 class I SAM-dependent methyltransferase -
SCL_RS02890 582413..582673 - 261 WP_096359830.1 metal-sensing transcriptional repressor -
SCL_RS02895 582834..584888 + 2055 WP_096359831.1 ferrous iron transporter B -
SCL_RS02900 584973..585572 + 600 WP_096359832.1 DUF502 domain-containing protein -
SCL_RS02905 585682..585960 + 279 WP_096359833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SCL_RS02910 585974..586258 + 285 WP_197702750.1 HigA family addiction module antidote protein Antitoxin
SCL_RS02915 586594..587010 + 417 WP_172425896.1 DUF4279 domain-containing protein -
SCL_RS14215 587187..587348 - 162 WP_172425897.1 hypothetical protein -
SCL_RS02920 587471..588493 - 1023 WP_096359836.1 tetratricopeptide repeat protein -
SCL_RS02925 588494..589000 - 507 WP_096359837.1 peptidylprolyl isomerase -
SCL_RS02930 589033..589386 - 354 WP_197702686.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-87)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10640.28 Da        Isoelectric Point: 10.3904

>T30996 WP_096359833.1 NZ_AP014879:585682-585960 [Sulfuricaulis limicola]
MIKSFRHKGLADLFHTGNARKVQAKHVKRLRLILTMLNAATQARQMDAPGLRLHPLKGKPEGRWAVDVDENYRVIFRFQE
GHACEVDYGDYH

Download         Length: 279 bp

>T30996 NZ_AP014879:585682-585960 [Sulfuricaulis limicola]
ATGATCAAGAGCTTCCGGCACAAGGGCCTGGCGGACCTGTTCCACACCGGCAACGCCCGCAAGGTTCAGGCCAAGCACGT
GAAGCGCCTGCGGCTGATCTTGACCATGCTCAACGCCGCCACCCAGGCACGGCAGATGGATGCCCCGGGGTTGCGGCTGC
ACCCCCTCAAGGGCAAGCCGGAAGGCCGCTGGGCGGTGGACGTGGATGAAAATTACCGCGTGATCTTCCGTTTCCAGGAA
GGCCACGCCTGCGAGGTGGACTATGGCGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10369.21 Da        Isoelectric Point: 10.9468

>AT30996 WP_197702750.1 NZ_AP014879:585974-586258 [Sulfuricaulis limicola]
MHNPAHPGEILREMYLKPLNITVTQAAKALGVSRKHVSAIVNGRAPVTPDMALRLASAFATEPELWVNMQAQYDLWAVSR
QARPKVKVLVKKAA

Download         Length: 285 bp

>AT30996 NZ_AP014879:585974-586258 [Sulfuricaulis limicola]
ATGCACAACCCCGCGCACCCGGGCGAAATTCTGCGGGAGATGTACCTGAAGCCCCTGAATATTACGGTCACTCAGGCCGC
CAAGGCGCTGGGCGTCAGTCGCAAGCACGTCTCGGCCATCGTGAATGGCCGCGCGCCGGTGACGCCGGACATGGCGCTGC
GCCTGGCTTCGGCCTTCGCCACTGAGCCCGAGCTGTGGGTGAACATGCAGGCGCAGTACGACCTGTGGGCGGTGAGCCGG
CAGGCACGGCCGAAAGTGAAGGTGCTGGTGAAGAAAGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References