Detailed information of TA system TA030977

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4597712..4598124
• Replicon: chromosome
• Accession: NZ_AP014857
• Organism: Escherichia albertii strain EC06-170

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: AST80_RS22430
• Protein ID: WP_059225014.1
• Coordinates: 4597712..4598053 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4598048..4598124 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AST80_RS22415	4594086..4595018	+	933	WP_059242218.1	Rpn family recombination-promoting nuclease/putative transposase	-
AST80_RS25090	4595171..4595344	-	174	Protein_4273	GntR family transcriptional regulator	-
AST80_RS25055	4595569..4597665	+	2097	WP_000648210.1	DUF262 domain-containing protein	-
AST80_RS22430	4597712..4598053	-	342	WP_059225014.1	endoribonuclease SymE	Toxin
-	4598048..4598124	+	77	NuclAT_6	-	Antitoxin
-	4598048..4598124	+	77	NuclAT_6	-	Antitoxin
-	4598048..4598124	+	77	NuclAT_6	-	Antitoxin
-	4598048..4598124	+	77	NuclAT_6	-	Antitoxin
-	4598048..4598124	+	77	NuclAT_7	-	Antitoxin
-	4598048..4598124	+	77	NuclAT_7	-	Antitoxin
-	4598048..4598124	+	77	NuclAT_7	-	Antitoxin
-	4598048..4598124	+	77	NuclAT_7	-	Antitoxin
AST80_RS22435	4598282..4599625	-	1344	WP_059235087.1	restriction endonuclease subunit S	-
AST80_RS22440	4599622..4601211	-	1590	WP_059235085.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12384.20 Da
• Isoelectric Point: 7.8219

>T30977 WP_059225014.1 NZ_AP014857:c4598053-4597712 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTTQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T30977 NZ_AP014857:c4598053-4597712 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTAATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT30977 NZ_AP014857:4598048-4598124 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin