Detailed information of TA system TA030974

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3691321..3691578
• Replicon: chromosome
• Accession: NZ_AP014857
• Organism: Escherichia albertii strain EC06-170

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: AST80_RS18060
• Protein ID: WP_001135738.1
• Coordinates: 3691321..3691473 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3691530..3691578 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AST80_RS18035	3687425..3688084	+	660	WP_000747625.1	OmpA family lipoprotein	-
AST80_RS18040	3688188..3689162	+	975	WP_059235571.1	glyoxylate/hydroxypyruvate reductase GhrB	-
AST80_RS18045	3689215..3689925	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
AST80_RS18050	3690348..3690638	+	291	WP_000455794.1	HTH-type transcriptional regulator	-
AST80_RS18055	3690921..3691133	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
AST80_RS18060	3691321..3691473	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	3691530..3691578	+	49	-	-	Antitoxin
AST80_RS18065	3691795..3693864	-	2070	WP_059235569.1	glycine--tRNA ligase subunit beta	-
AST80_RS18070	3693874..3694785	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
AST80_RS18075	3694881..3695180	-	300	WP_000979961.1	YsaB family lipoprotein	-
AST80_RS18080	3695353..3696348	+	996	WP_059235567.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T30974 WP_001135738.1 NZ_AP014857:c3691473-3691321 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T30974 NZ_AP014857:c3691473-3691321 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT30974 NZ_AP014857:3691530-3691578 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin