Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2817162..2817407 Replicon chromosome
Accession NZ_AP014857
Organism Escherichia albertii strain EC06-170

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag AST80_RS13765 Protein ID WP_000956458.1
Coordinates 2817162..2817314 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 2817359..2817407 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST80_RS13740 2812431..2812754 - 324 WP_001246114.1 DUF3561 family protein -
AST80_RS13745 2812804..2813409 - 606 WP_024164730.1 adenylyl-sulfate kinase -
AST80_RS13750 2813409..2814836 - 1428 WP_054412002.1 sulfate adenylyltransferase subunit CysN -
AST80_RS13755 2814838..2815746 - 909 WP_000372392.1 sulfate adenylyltransferase subunit CysD -
AST80_RS13760 2816000..2817037 + 1038 WP_059235902.1 alkaline phosphatase isozyme conversion aminopeptidase -
AST80_RS13765 2817162..2817314 - 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
- 2817359..2817407 + 49 - - Antitoxin
AST80_RS13770 2817578..2818312 - 735 WP_060877433.1 phosphoadenosine phosphosulfate reductase -
AST80_RS13775 2818492..2820204 - 1713 WP_060877434.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
AST80_RS13780 2820204..2822003 - 1800 WP_060877435.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T30968 WP_000956458.1 NZ_AP014857:c2817314-2817162 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T30968 NZ_AP014857:c2817314-2817162 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 49 bp

>AT30968 NZ_AP014857:2817359-2817407 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References