Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1541834..1542396 Replicon chromosome
Accession NZ_AP014857
Organism Escherichia albertii strain EC06-170

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AST80_RS07475 Protein ID WP_060877298.1
Coordinates 1542118..1542396 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AST80_RS07470 Protein ID WP_000781369.1
Coordinates 1541834..1542118 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST80_RS07455 1537016..1540063 + 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -
AST80_RS07460 1540076..1540960 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
AST80_RS07465 1540953..1541606 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
AST80_RS07470 1541834..1542118 - 285 WP_000781369.1 HigA family addiction module antidote protein Antitoxin
AST80_RS07475 1542118..1542396 - 279 WP_060877298.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AST80_RS07480 1542582..1543592 - 1011 WP_000642386.1 alcohol dehydrogenase AdhP -
AST80_RS07485 1543727..1545424 - 1698 WP_000433442.1 malate dehydrogenase -
AST80_RS07490 1545575..1545712 - 138 WP_060877299.1 stationary-phase-induced ribosome-associated protein -
AST80_RS07495 1545979..1546410 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10563.12 Da        Isoelectric Point: 7.3995

>T30958 WP_060877298.1 NZ_AP014857:c1542396-1542118 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDSIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T30958 NZ_AP014857:c1542396-1542118 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATAGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT30958 WP_000781369.1 NZ_AP014857:c1542118-1541834 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp

>AT30958 NZ_AP014857:c1542118-1541834 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References