Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15566..15824 Replicon chromosome
Accession NZ_AP014857
Organism Escherichia albertii strain EC06-170

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AST80_RS00080 Protein ID WP_000809168.1
Coordinates 15566..15718 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15767..15824 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST80_RS00060 10804..11517 - 714 WP_001102345.1 acidic protein MsyB -
AST80_RS00065 11544..11948 - 405 WP_000833521.1 DUF2541 family protein -
AST80_RS00070 12323..14239 + 1917 WP_000516135.1 molecular chaperone DnaK -
AST80_RS00075 14328..15458 + 1131 WP_001118445.1 molecular chaperone DnaJ -
AST80_RS00080 15566..15718 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15767..15824 + 58 - - Antitoxin
AST80_RS00085 16341..17102 + 762 WP_001276206.1 membrane protein -
AST80_RS00090 17123..18616 + 1494 WP_059214855.1 sulfatase-like hydrolase/transferase -
AST80_RS00095 18770..20017 + 1248 WP_059235056.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T30954 WP_000809168.1 NZ_AP014857:c15718-15566 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T30954 NZ_AP014857:c15718-15566 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT30954 NZ_AP014857:15767-15824 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References