Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3663845..3664102 Replicon chromosome
Accession NZ_AP014856
Organism Escherichia albertii strain CB9786

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag AST72_RS18755 Protein ID WP_001135738.1
Coordinates 3663845..3663997 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 3664054..3664102 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST72_RS18730 3659950..3660609 + 660 WP_000747625.1 OmpA family lipoprotein -
AST72_RS18735 3660713..3661687 + 975 WP_095576123.1 glyoxylate/hydroxypyruvate reductase GhrB -
AST72_RS18740 3661740..3662450 - 711 WP_002460072.1 DUF3053 domain-containing protein -
AST72_RS18745 3662873..3663163 + 291 WP_059221281.1 HTH-type transcriptional regulator -
AST72_RS18750 3663446..3663658 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
AST72_RS18755 3663845..3663997 - 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
- 3664054..3664102 + 49 - - Antitoxin
AST72_RS18760 3664319..3666388 - 2070 WP_001291807.1 glycine--tRNA ligase subunit beta -
AST72_RS18765 3666398..3667309 - 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
AST72_RS18770 3667405..3667704 - 300 WP_000979961.1 YsaB family lipoprotein -
AST72_RS18775 3667877..3668872 + 996 WP_059221277.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T30952 WP_001135738.1 NZ_AP014856:c3663997-3663845 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T30952 NZ_AP014856:c3663997-3663845 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 49 bp

>AT30952 NZ_AP014856:3664054-3664102 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References