Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1534833..1535395 Replicon chromosome
Accession NZ_AP014856
Organism Escherichia albertii strain CB9786

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AST72_RS07830 Protein ID WP_059276333.1
Coordinates 1535117..1535395 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag AST72_RS07825 Protein ID WP_000781370.1
Coordinates 1534833..1535117 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST72_RS07810 1530015..1533062 + 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -
AST72_RS07815 1533075..1533959 + 885 WP_059268408.1 formate dehydrogenase N subunit beta -
AST72_RS07820 1533952..1534605 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
AST72_RS07825 1534833..1535117 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
AST72_RS07830 1535117..1535395 - 279 WP_059276333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AST72_RS07835 1535581..1536591 - 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
AST72_RS07840 1536726..1538423 - 1698 WP_000433442.1 malate dehydrogenase -
AST72_RS07850 1538580..1538717 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
AST72_RS07855 1538975..1539406 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10481.08 Da        Isoelectric Point: 7.2751

>T30938 WP_059276333.1 NZ_AP014856:c1535395-1535117 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T30938 NZ_AP014856:c1535395-1535117 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGTTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
CCCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT30938 WP_000781370.1 NZ_AP014856:c1535117-1534833 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT30938 NZ_AP014856:c1535117-1534833 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References