Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3596496..3596753 Replicon chromosome
Accession NZ_AP014855
Organism Escherichia albertii strain NIAH_Bird_3

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag AST93_RS17865 Protein ID WP_001135738.1
Coordinates 3596496..3596648 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 3596705..3596753 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST93_RS17840 3592600..3593259 + 660 WP_000747625.1 OmpA family lipoprotein -
AST93_RS17845 3593363..3594337 + 975 WP_059221283.1 glyoxylate/hydroxypyruvate reductase GhrB -
AST93_RS17850 3594390..3595100 - 711 WP_002460072.1 DUF3053 domain-containing protein -
AST93_RS17855 3595523..3595813 + 291 WP_059221281.1 HTH-type transcriptional regulator -
AST93_RS17860 3596096..3596308 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
AST93_RS17865 3596496..3596648 - 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
- 3596705..3596753 + 49 - - Antitoxin
AST93_RS17870 3596970..3599039 - 2070 WP_095574339.1 glycine--tRNA ligase subunit beta -
AST93_RS17875 3599049..3599960 - 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
AST93_RS17880 3600056..3600355 - 300 WP_000979961.1 YsaB family lipoprotein -
AST93_RS17885 3600528..3601523 + 996 WP_059221277.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T30930 WP_001135738.1 NZ_AP014855:c3596648-3596496 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T30930 NZ_AP014855:c3596648-3596496 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 49 bp

>AT30930 NZ_AP014855:3596705-3596753 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References