Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5576734..5577329 Replicon chromosome
Accession NZ_AP014839
Organism Pseudomonas aeruginosa strain 8380

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PA8380_RS31595 Protein ID WP_071538299.1
Coordinates 5577051..5577329 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PA8380_RS25915 Protein ID WP_003123432.1
Coordinates 5576734..5577039 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA8380_RS25895 5571915..5572250 + 336 WP_025921265.1 hypothetical protein -
PA8380_RS25900 5572260..5572649 + 390 WP_025921264.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
PA8380_RS31580 5572729..5573466 + 738 WP_115658289.1 HNH endonuclease -
PA8380_RS31585 5573472..5574398 - 927 WP_196664244.1 DNA-protecting protein DprA -
PA8380_RS31590 5574440..5575675 - 1236 WP_158514232.1 HAD hydrolase-like protein -
PA8380_RS25910 5576021..5576398 - 378 WP_025921262.1 hypothetical protein -
PA8380_RS25915 5576734..5577039 - 306 WP_003123432.1 HigA family addiction module antidote protein Antitoxin
PA8380_RS31595 5577051..5577329 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PA8380_RS25920 5577658..5579886 + 2229 WP_003113525.1 TonB-dependent receptor -
PA8380_RS25925 5579956..5580603 - 648 WP_003095021.1 carbonate dehydratase -
PA8380_RS25930 5580665..5581903 - 1239 WP_017148591.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T30906 WP_071538299.1 NZ_AP014839:c5577329-5577051 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T30906 NZ_AP014839:c5577329-5577051 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT30906 WP_003123432.1 NZ_AP014839:c5577039-5576734 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT30906 NZ_AP014839:c5577039-5576734 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References