Detailed information of TA system TA030884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 37144..37661
• Replicon: plasmid Plasmid2 DNA
• Accession: NZ_AP014802
• Organism: Rhodovulum sulfidophilum

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A0D6B8Z2
• Locus tag: NHU_RS21210
• Protein ID: WP_060836716.1
• Coordinates: 37392..37661 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A8I1IQM1
• Locus tag: NHU_RS21205
• Protein ID: WP_060836715.1
• Coordinates: 37144..37395 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NHU_RS21185	32522..33046	+	525	WP_060836711.1	hypothetical protein	-
NHU_RS21190	33216..33731	-	516	WP_060836712.1	hypothetical protein	-
NHU_RS21195	34293..34553	-	261	WP_060836713.1	PAAR domain-containing protein	-
NHU_RS21200	34553..36601	-	2049	WP_060836714.1	type VI secretion system tip protein VgrG	-
NHU_RS21205	37144..37395	+	252	WP_060836715.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
NHU_RS21210	37392..37661	+	270	WP_060836716.1	Txe/YoeB family addiction module toxin	Toxin
NHU_RS21215	38352..40130	-	1779	WP_060836717.1	ABC transporter ATP-binding protein/permease	-
NHU_RS21220	40127..41950	-	1824	WP_060836718.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..106137	106137

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10686.11 Da
• Isoelectric Point: 10.0567

>T30884 WP_060836716.1 NZ_AP014802:37392-37661 [Rhodovulum sulfidophilum]
VKIVFSDNAWEDYLWWQSPGHEKELERINTLIKSATRTPFKGLGKPEPLKGDLRGWWSRRITDEHRFVYRVRGKGDEQSL
QIAQLRYHY

Nucleotide

• Length: 270 bp

>T30884 NZ_AP014802:37392-37661 [Rhodovulum sulfidophilum]
GTGAAGATCGTCTTTTCGGACAATGCCTGGGAGGACTATCTCTGGTGGCAATCGCCGGGACACGAGAAGGAACTGGAGCG
CATCAACACCCTCATCAAGTCTGCCACCAGAACGCCGTTCAAGGGCCTGGGCAAGCCGGAACCGCTGAAGGGAGATCTTC
GCGGCTGGTGGTCGCGGCGGATCACGGACGAACATCGCTTCGTCTATCGCGTCAGAGGCAAGGGGGATGAGCAATCGTTG
CAGATTGCCCAACTGCGCTACCATTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9375.62 Da
• Isoelectric Point: 4.8500

>AT30884 WP_060836715.1 NZ_AP014802:37144-37395 [Rhodovulum sulfidophilum]
MHVISYTDARASLKDVMDRVIHDRDEVIVTRKKNEAVVMIGLDEYNAIQETLHLLKSPENAARLRSSIAQLEAGEGTERD
IDL

Nucleotide

• Length: 252 bp

>AT30884 NZ_AP014802:37144-37395 [Rhodovulum sulfidophilum]
ATGCACGTTATCTCCTATACCGACGCGCGCGCCTCCCTGAAGGACGTGATGGACCGGGTGATCCATGATCGCGACGAGGT
CATCGTGACCCGCAAGAAGAACGAGGCGGTGGTGATGATCGGGCTGGACGAATACAACGCCATCCAGGAAACCCTGCATC
TTCTCAAGAGCCCCGAAAACGCGGCACGCCTGCGGTCATCCATCGCCCAGCTGGAGGCCGGCGAGGGCACCGAGCGCGAC
ATCGACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0D6B8Z2