Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6187740..6188412 Replicon chromosome
Accession NZ_AP014703
Organism Pseudomonas sp. St290

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PBDP_RS27185 Protein ID WP_109754987.1
Coordinates 6188047..6188412 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PBDP_RS27180 Protein ID WP_109754986.1
Coordinates 6187740..6188054 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBDP_RS27170 (PBDP_5360) 6184787..6187219 + 2433 WP_249411826.1 hypothetical protein -
PBDP_RS27175 (PBDP_5361) 6187256..6187717 + 462 WP_018607342.1 Lrp/AsnC family transcriptional regulator -
PBDP_RS27180 (PBDP_5362) 6187740..6188054 - 315 WP_109754986.1 XRE family transcriptional regulator Antitoxin
PBDP_RS27185 (PBDP_5363) 6188047..6188412 - 366 WP_109754987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PBDP_RS27190 (PBDP_5364) 6188773..6190455 + 1683 WP_212801543.1 NAD(P)/FAD-dependent oxidoreductase -
PBDP_RS27195 (PBDP_5365) 6190468..6191262 + 795 WP_109754989.1 carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14013.68 Da        Isoelectric Point: 4.9669

>T30876 WP_109754987.1 NZ_AP014703:c6188412-6188047 [Pseudomonas sp. St290]
MKWDVEYTDEFEMWWSCLSETEQDSVQASVMLLGDAGPHLGFPHTSDIKGSRHGNLRELRVQHAGRPYRVLYAFDPRRCA
ILLIGGDKTGQDRWYQECVPLAERLYDEHLEALKREGFDNG

Download         Length: 366 bp

>T30876 NZ_AP014703:c6188412-6188047 [Pseudomonas sp. St290]
ATGAAATGGGACGTTGAATACACCGACGAATTTGAGATGTGGTGGAGCTGTCTCAGTGAGACCGAGCAAGATTCAGTGCA
GGCCTCGGTGATGCTGCTTGGCGATGCCGGGCCGCATCTGGGTTTTCCTCACACCAGTGATATCAAGGGCTCGCGTCATG
GCAACCTTCGTGAGTTACGAGTACAACACGCAGGTAGGCCTTATCGTGTGCTCTATGCGTTTGATCCACGCCGTTGCGCC
ATCCTGCTGATCGGGGGAGACAAAACCGGCCAGGACCGTTGGTATCAGGAATGTGTGCCTTTGGCTGAACGTCTCTATGA
CGAGCATCTGGAAGCATTGAAGAGAGAGGGCTTTGACAATGGCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12002.75 Da        Isoelectric Point: 9.9863

>AT30876 WP_109754986.1 NZ_AP014703:c6188054-6187740 [Pseudomonas sp. St290]
MAKKFSDLIARRSPDSRARAETLYQKLRAEMPLHELRQAQELSQDALAKTLHINQAAVSKMERRTDMYISTLRNYIRAMG
GELEIIATFPEGQVRIENFAHQTQ

Download         Length: 315 bp

>AT30876 NZ_AP014703:c6188054-6187740 [Pseudomonas sp. St290]
ATGGCTAAGAAATTTTCCGACTTGATTGCACGTCGTTCGCCTGACTCCCGGGCTCGTGCAGAGACTCTGTATCAGAAACT
GCGTGCAGAAATGCCGTTGCACGAGTTGCGTCAGGCGCAGGAGCTGAGCCAGGATGCTTTGGCCAAGACGCTGCATATCA
ACCAGGCGGCAGTCTCGAAAATGGAACGCCGTACCGACATGTACATCAGTACGCTACGAAATTACATCCGCGCCATGGGG
GGGGAATTGGAGATTATCGCGACCTTCCCGGAGGGGCAGGTCAGGATCGAAAACTTCGCCCATCAAACACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References