Detailed information of TA system TA030875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 5596477..5597132
• Replicon: chromosome
• Accession: NZ_AP014703
• Organism: Pseudomonas sp. St290

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: PBDP_RS24425
• Protein ID: WP_109754833.1
• Coordinates: 5596788..5597132 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: PBDP_RS24420
• Protein ID: WP_003205391.1
• Coordinates: 5596477..5596791 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PBDP_RS24400 (PBDP_4826)	5592386..5593303	+	918	WP_109754829.1	LysR family transcriptional regulator	-
PBDP_RS24405 (PBDP_4827)	5593547..5594560	+	1014	WP_109754830.1	sensor domain-containing diguanylate cyclase	-
PBDP_RS24410 (PBDP_4828)	5594653..5595396	+	744	WP_212801427.1	DUF72 domain-containing protein	-
PBDP_RS24415 (PBDP_4829)	5595535..5596239	+	705	WP_212801428.1	hypothetical protein	-
PBDP_RS24420 (PBDP_4830)	5596477..5596791	-	315	WP_003205391.1	helix-turn-helix domain-containing protein	Antitoxin
PBDP_RS24425 (PBDP_4831)	5596788..5597132	-	345	WP_109754833.1	toxin	Toxin
PBDP_RS24430 (PBDP_4832)	5597272..5598159	-	888	WP_109754834.1	heme o synthase	-
PBDP_RS24435 (PBDP_4833)	5598171..5598506	-	336	WP_025211927.1	cytochrome o ubiquinol oxidase subunit IV	-
PBDP_RS24440 (PBDP_4834)	5598507..5599133	-	627	WP_109754835.1	cytochrome o ubiquinol oxidase subunit III	-
PBDP_RS24445 (PBDP_4835)	5599137..5601167	-	2031	WP_109754836.1	cytochrome o ubiquinol oxidase subunit I	-
PBDP_RS24450 (PBDP_4836)	5601171..5602118	-	948	WP_003205397.1	ubiquinol oxidase subunit II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-87)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13680.71 Da
• Isoelectric Point: 9.2887

>T30875 WP_109754833.1 NZ_AP014703:c5597132-5596788 [Pseudomonas sp. St290]
MRTLFFETTTFTATVGHYLTDDEYRLLQSYMLEHPEVGDVMPRTGGFRKLRWFDERRGKGKRGGLRVIYYWLMNDRQFWM
FAIYDKDELVNLTSEQEKTLKRAIEAELKVRGTL

Nucleotide

• Length: 345 bp

>T30875 NZ_AP014703:c5597132-5596788 [Pseudomonas sp. St290]
ATGCGTACCCTGTTTTTTGAAACGACCACATTCACCGCCACGGTTGGCCATTACCTGACTGATGATGAGTATCGTCTGCT
TCAGTCCTATATGCTGGAGCATCCAGAGGTCGGTGACGTCATGCCACGTACCGGCGGCTTTCGTAAGCTGCGCTGGTTCG
ATGAGCGTCGTGGCAAAGGGAAGCGGGGTGGGTTGCGAGTCATTTACTATTGGCTCATGAACGATCGTCAGTTTTGGATG
TTCGCGATTTATGACAAGGACGAGTTGGTAAACCTGACCTCCGAGCAAGAGAAGACGCTCAAGCGCGCCATAGAAGCTGA
GTTGAAAGTACGAGGTACCTTATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11771.76 Da
• Isoelectric Point: 9.8409

>AT30875 WP_003205391.1 NZ_AP014703:c5596791-5596477 [Pseudomonas sp. St290]
MKKRDLFAEMMQGVEEMAAHREGKITLRQISIEDKPVPEVSAQEIVALRDKLHMSQAVFAKSIRTSPGTLRNWEQEKSKP
NAQAALLIKLVEKFPDMVERLGAV

Nucleotide

• Length: 315 bp

>AT30875 NZ_AP014703:c5596791-5596477 [Pseudomonas sp. St290]
ATGAAAAAGCGCGATCTGTTTGCCGAGATGATGCAAGGCGTCGAGGAGATGGCCGCTCACCGCGAGGGCAAGATTACCCT
TCGCCAGATATCGATCGAAGACAAACCGGTTCCCGAGGTGTCGGCCCAGGAAATCGTGGCTTTGCGCGACAAGCTCCACA
TGTCCCAAGCCGTTTTCGCCAAGAGCATCAGGACCAGTCCAGGTACCCTGAGAAATTGGGAACAGGAAAAATCCAAGCCT
AACGCCCAGGCGGCTTTGTTGATCAAACTGGTCGAGAAGTTTCCAGATATGGTCGAACGACTTGGCGCTGTTTGA