Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 5596477..5597132 Replicon chromosome
Accession NZ_AP014703
Organism Pseudomonas sp. St290

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PBDP_RS24425 Protein ID WP_109754833.1
Coordinates 5596788..5597132 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PBDP_RS24420 Protein ID WP_003205391.1
Coordinates 5596477..5596791 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBDP_RS24400 (PBDP_4826) 5592386..5593303 + 918 WP_109754829.1 LysR family transcriptional regulator -
PBDP_RS24405 (PBDP_4827) 5593547..5594560 + 1014 WP_109754830.1 sensor domain-containing diguanylate cyclase -
PBDP_RS24410 (PBDP_4828) 5594653..5595396 + 744 WP_212801427.1 DUF72 domain-containing protein -
PBDP_RS24415 (PBDP_4829) 5595535..5596239 + 705 WP_212801428.1 hypothetical protein -
PBDP_RS24420 (PBDP_4830) 5596477..5596791 - 315 WP_003205391.1 helix-turn-helix domain-containing protein Antitoxin
PBDP_RS24425 (PBDP_4831) 5596788..5597132 - 345 WP_109754833.1 toxin Toxin
PBDP_RS24430 (PBDP_4832) 5597272..5598159 - 888 WP_109754834.1 heme o synthase -
PBDP_RS24435 (PBDP_4833) 5598171..5598506 - 336 WP_025211927.1 cytochrome o ubiquinol oxidase subunit IV -
PBDP_RS24440 (PBDP_4834) 5598507..5599133 - 627 WP_109754835.1 cytochrome o ubiquinol oxidase subunit III -
PBDP_RS24445 (PBDP_4835) 5599137..5601167 - 2031 WP_109754836.1 cytochrome o ubiquinol oxidase subunit I -
PBDP_RS24450 (PBDP_4836) 5601171..5602118 - 948 WP_003205397.1 ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(47-87)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13680.71 Da        Isoelectric Point: 9.2887

>T30875 WP_109754833.1 NZ_AP014703:c5597132-5596788 [Pseudomonas sp. St290]
MRTLFFETTTFTATVGHYLTDDEYRLLQSYMLEHPEVGDVMPRTGGFRKLRWFDERRGKGKRGGLRVIYYWLMNDRQFWM
FAIYDKDELVNLTSEQEKTLKRAIEAELKVRGTL

Download         Length: 345 bp

>T30875 NZ_AP014703:c5597132-5596788 [Pseudomonas sp. St290]
ATGCGTACCCTGTTTTTTGAAACGACCACATTCACCGCCACGGTTGGCCATTACCTGACTGATGATGAGTATCGTCTGCT
TCAGTCCTATATGCTGGAGCATCCAGAGGTCGGTGACGTCATGCCACGTACCGGCGGCTTTCGTAAGCTGCGCTGGTTCG
ATGAGCGTCGTGGCAAAGGGAAGCGGGGTGGGTTGCGAGTCATTTACTATTGGCTCATGAACGATCGTCAGTTTTGGATG
TTCGCGATTTATGACAAGGACGAGTTGGTAAACCTGACCTCCGAGCAAGAGAAGACGCTCAAGCGCGCCATAGAAGCTGA
GTTGAAAGTACGAGGTACCTTATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11771.76 Da        Isoelectric Point: 9.8409

>AT30875 WP_003205391.1 NZ_AP014703:c5596791-5596477 [Pseudomonas sp. St290]
MKKRDLFAEMMQGVEEMAAHREGKITLRQISIEDKPVPEVSAQEIVALRDKLHMSQAVFAKSIRTSPGTLRNWEQEKSKP
NAQAALLIKLVEKFPDMVERLGAV

Download         Length: 315 bp

>AT30875 NZ_AP014703:c5596791-5596477 [Pseudomonas sp. St290]
ATGAAAAAGCGCGATCTGTTTGCCGAGATGATGCAAGGCGTCGAGGAGATGGCCGCTCACCGCGAGGGCAAGATTACCCT
TCGCCAGATATCGATCGAAGACAAACCGGTTCCCGAGGTGTCGGCCCAGGAAATCGTGGCTTTGCGCGACAAGCTCCACA
TGTCCCAAGCCGTTTTCGCCAAGAGCATCAGGACCAGTCCAGGTACCCTGAGAAATTGGGAACAGGAAAAATCCAAGCCT
AACGCCCAGGCGGCTTTGTTGATCAAACTGGTCGAGAAGTTTCCAGATATGGTCGAACGACTTGGCGCTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References