Detailed information of TA system TA030868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2487662..2488185
• Replicon: chromosome
• Accession: NZ_AP014653
• Organism: Staphylococcus aureus strain TMUS2134

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: SAJPND4_RS12585
• Protein ID: WP_000074043.1
• Coordinates: 2487662..2487928 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: SAJPND4_RS12590
• Protein ID: WP_000587618.1
• Coordinates: 2487928..2488185 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAJPND4_RS12565	2482968..2484155	-	1188	WP_000026187.1	MFS transporter	-
SAJPND4_RS12570	2484551..2485327	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
SAJPND4_RS12575	2485320..2485982	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
SAJPND4_RS12580	2486230..2487306	-	1077	WP_001076665.1	M42 family metallopeptidase	-
SAJPND4_RS12585	2487662..2487928	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
SAJPND4_RS12590	2487928..2488185	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SAJPND4_RS12600	2488545..2489000	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
SAJPND4_RS12605	2489168..2490745	-	1578	WP_000143508.1	FMN-binding glutamate synthase family protein	-
SAJPND4_RS12610	2490941..2491690	+	750	WP_000072441.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T30868 WP_000074043.1 NZ_AP014653:c2487928-2487662 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T30868 NZ_AP014653:c2487928-2487662 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT30868 WP_000587618.1 NZ_AP014653:c2488185-2487928 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT30868 NZ_AP014653:c2488185-2487928 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2