Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2456481..2456665 Replicon chromosome
Accession NZ_AP014653
Organism Staphylococcus aureus strain TMUS2134

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag SAJPND4_RS12430 Protein ID WP_000482650.1
Coordinates 2456558..2456665 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2456481..2456541 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJPND4_RS12405 2451991..2452158 - 168 WP_001792506.1 hypothetical protein -
SAJPND4_RS12415 2452389..2454122 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
SAJPND4_RS12420 2454147..2455910 - 1764 WP_001064820.1 ABC transporter ATP-binding protein/permease -
- 2456481..2456541 + 61 - - Antitoxin
SAJPND4_RS12430 2456558..2456665 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
SAJPND4_RS12435 2456799..2457185 - 387 WP_000779358.1 flippase GtxA -
SAJPND4_RS12440 2457443..2458585 + 1143 WP_001176863.1 glycerate kinase -
SAJPND4_RS12445 2458645..2459304 + 660 WP_000831298.1 membrane protein -
SAJPND4_RS12450 2459486..2460697 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAJPND4_RS12455 2460820..2461293 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T30866 WP_000482650.1 NZ_AP014653:c2456665-2456558 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T30866 NZ_AP014653:c2456665-2456558 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT30866 NZ_AP014653:2456481-2456541 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References