Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2173854..2174070 Replicon chromosome
Accession NZ_AP014652
Organism Staphylococcus aureus strain TMUS2126

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAJPND1_RS10975 Protein ID WP_001802298.1
Coordinates 2173966..2174070 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2173854..2173909 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJPND1_RS10955 2170057..2170722 - 666 WP_001024095.1 SDR family oxidoreductase -
SAJPND1_RS10960 2170874..2171194 + 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAJPND1_RS10965 2171196..2172176 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
SAJPND1_RS10970 2172442..2173533 + 1092 WP_000495681.1 hypothetical protein -
- 2173854..2173909 + 56 - - Antitoxin
SAJPND1_RS10975 2173966..2174070 - 105 WP_001802298.1 hypothetical protein Toxin
SAJPND1_RS10985 2174750..2174908 + 159 WP_001792784.1 hypothetical protein -
SAJPND1_RS10995 2175566..2176423 - 858 WP_000370928.1 Cof-type HAD-IIB family hydrolase -
SAJPND1_RS11000 2176491..2177273 - 783 WP_000908189.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T30848 WP_001802298.1 NZ_AP014652:c2174070-2173966 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T30848 NZ_AP014652:c2174070-2173966 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT30848 NZ_AP014652:2173854-2173909 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References