Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4413637..4414291 Replicon chromosome
Accession NZ_AP014628
Organism Pseudomonas sp. St29

Toxin (Protein)


Gene name higB Uniprot ID A0A0D6BLD7
Locus tag PST29_RS19545 Protein ID WP_060840140.1
Coordinates 4413637..4413987 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0D6BLA0
Locus tag PST29_RS19550 Protein ID WP_060840141.1
Coordinates 4413974..4414291 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PST29_RS19535 4410396..4411928 + 1533 WP_016965722.1 NADH-quinone oxidoreductase subunit M -
PST29_RS19540 4411936..4413399 + 1464 WP_015636299.1 NADH-quinone oxidoreductase subunit NuoN -
PST29_RS19545 4413637..4413987 + 351 WP_060840140.1 hypothetical protein Toxin
PST29_RS19550 4413974..4414291 + 318 WP_060840141.1 XRE family transcriptional regulator Antitoxin
PST29_RS19555 4414364..4415746 - 1383 WP_060844109.1 cysteine--tRNA ligase -
PST29_RS19560 4415765..4417465 - 1701 WP_060844110.1 glutamine--tRNA ligase/YqeY domain fusion protein -
PST29_RS19565 4417736..4418239 + 504 WP_060840144.1 peptidyl-prolyl cis-trans isomerase -
PST29_RS19570 4418236..4418988 + 753 WP_060840145.1 UDP-2,3-diacylglucosamine diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(48-101)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 14022.12 Da        Isoelectric Point: 8.9935

>T30795 WP_060840140.1 NZ_AP014628:4413637-4413987 [Pseudomonas sp. St29]
MNALFIELPAFARYRRDFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFIDERRNKGRRGGLRVIYYWWSGGAQFWL
FTLFDKEQMDDLLPQQRQQLKQLLEREIEARRHDQT

Download         Length: 351 bp

>T30795 NZ_AP014628:4413637-4413987 [Pseudomonas sp. St29]
ATGAATGCTCTGTTTATTGAACTGCCGGCATTTGCACGATACCGAAGGGACTTCCTTGACGACGAGTTGTTCTGCGAACT
GCAGATCGAGTTGCTGCGCCACCCGCACGCGGGAGTGCTGATTCAGGGCACTGGCGGCTTGCGCAAGATGCGTTTCATCG
ATGAGCGACGCAACAAGGGCAGGCGTGGCGGGCTGAGGGTGATCTATTACTGGTGGTCCGGAGGGGCGCAGTTCTGGCTC
TTCACCCTGTTCGATAAGGAGCAGATGGACGACCTGCTACCGCAGCAGCGACAACAGCTCAAACAACTGCTGGAACGTGA
AATCGAGGCCAGAAGACATGACCAAACGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12067.91 Da        Isoelectric Point: 10.7043

>AT30795 WP_060840141.1 NZ_AP014628:4413974-4414291 [Pseudomonas sp. St29]
MTKRDIFSELVEGIDALTQERQGKITLRSHKVKLDKLPPITATEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRATP
NAQATTLIRLVQRYPDTVERLASLA

Download         Length: 318 bp

>AT30795 NZ_AP014628:4413974-4414291 [Pseudomonas sp. St29]
ATGACCAAACGTGACATCTTTTCCGAACTGGTAGAAGGCATCGACGCCCTCACCCAGGAGCGCCAGGGCAAGATCACCCT
GCGCAGCCATAAAGTGAAGCTGGACAAGCTGCCCCCCATCACTGCCACCGAGGTGATGAACATCCGCCAGCAACTCAATC
TCTCGCGCTCGGTATTCGCCATGTACCTGCGCACCAACACCCGCACCCTGGAGAACTGGGAACAGGGCCGTGCCACACCC
AATGCCCAGGCCACCACCCTGATCCGCCTGGTGCAACGCTACCCCGATACCGTGGAGCGCCTAGCCTCGCTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6BLD7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6BLA0

References