Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4517902..4518556 Replicon chromosome
Accession NZ_AP014627
Organism Pseudomonas sp. Os17

Toxin (Protein)


Gene name higB Uniprot ID A0A0D6BLD7
Locus tag POS17_RS19820 Protein ID WP_060840140.1
Coordinates 4517902..4518252 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0D6BLA0
Locus tag POS17_RS19825 Protein ID WP_060840141.1
Coordinates 4518239..4518556 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
POS17_RS19810 4514661..4516193 + 1533 WP_016965722.1 NADH-quinone oxidoreductase subunit M -
POS17_RS19815 4516201..4517664 + 1464 WP_015636299.1 NADH-quinone oxidoreductase subunit NuoN -
POS17_RS19820 4517902..4518252 + 351 WP_060840140.1 hypothetical protein Toxin
POS17_RS19825 4518239..4518556 + 318 WP_060840141.1 XRE family transcriptional regulator Antitoxin
POS17_RS19830 4518629..4520011 - 1383 WP_060840142.1 cysteine--tRNA ligase -
POS17_RS19835 4520030..4521730 - 1701 WP_060840143.1 glutamine--tRNA ligase/YqeY domain fusion protein -
POS17_RS19840 4522001..4522504 + 504 WP_060840144.1 peptidyl-prolyl cis-trans isomerase -
POS17_RS19845 4522501..4523253 + 753 WP_060840145.1 UDP-2,3-diacylglucosamine diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(48-101)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 14022.12 Da        Isoelectric Point: 8.9935

>T30786 WP_060840140.1 NZ_AP014627:4517902-4518252 [Pseudomonas sp. Os17]
MNALFIELPAFARYRRDFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFIDERRNKGRRGGLRVIYYWWSGGAQFWL
FTLFDKEQMDDLLPQQRQQLKQLLEREIEARRHDQT

Download         Length: 351 bp

>T30786 NZ_AP014627:4517902-4518252 [Pseudomonas sp. Os17]
ATGAATGCTCTGTTTATTGAACTGCCGGCATTTGCACGATACCGAAGGGACTTCCTTGACGACGAGTTGTTCTGCGAACT
GCAGATCGAATTGCTGCGCCACCCGCACGCGGGAGTGCTGATTCAGGGCACTGGCGGCTTGCGCAAGATGCGTTTCATCG
ATGAGCGACGCAACAAGGGCAGGCGTGGCGGGCTGAGGGTGATCTATTACTGGTGGTCCGGAGGGGCGCAGTTCTGGCTC
TTCACCCTGTTCGACAAGGAGCAGATGGACGACCTGCTACCGCAGCAGCGACAACAGCTCAAACAACTGCTGGAACGTGA
AATCGAGGCCAGAAGACATGACCAAACGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12067.91 Da        Isoelectric Point: 10.7043

>AT30786 WP_060840141.1 NZ_AP014627:4518239-4518556 [Pseudomonas sp. Os17]
MTKRDIFSELVEGIDALTQERQGKITLRSHKVKLDKLPPITATEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRATP
NAQATTLIRLVQRYPDTVERLASLA

Download         Length: 318 bp

>AT30786 NZ_AP014627:4518239-4518556 [Pseudomonas sp. Os17]
ATGACCAAACGTGACATCTTTTCCGAACTGGTAGAAGGCATCGACGCCCTCACCCAGGAGCGCCAGGGCAAAATCACCCT
GCGCAGCCATAAAGTGAAGCTGGACAAGCTGCCCCCCATCACTGCCACCGAGGTGATGAACATCCGCCAGCAACTCAATC
TCTCGCGCTCGGTATTCGCCATGTACCTGCGCACCAACACCCGCACCCTGGAGAACTGGGAACAGGGCCGCGCCACACCC
AATGCCCAGGCCACCACCCTGATCCGCCTGGTGCAACGCTACCCCGATACCGTGGAGCGCCTAGCCTCGCTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6BLD7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6BLA0

References