Detailed information of TA system TA030759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1481571..1482271
• Replicon: chromosome
• Accession: NZ_AP014582
• Organism: Bordetella bronchiseptica strain S798

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3LPJ8
• Locus tag: BBS798_RS06915
• Protein ID: WP_003809515.1
• Coordinates: 1481571..1481867 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: BBS798_RS06920
• Protein ID: WP_003809516.1
• Coordinates: 1481870..1482271 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBS798_RS06895	1477867..1478409	+	543	WP_010926149.1	molybdenum cofactor biosysynthesis protein	-
BBS798_RS06900	1478585..1479649	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
BBS798_RS06905	1479735..1480181	-	447	WP_003809511.1	GFA family protein	-
BBS798_RS06910	1480407..1481288	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
BBS798_RS06915	1481571..1481867	+	297	WP_003809515.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BBS798_RS06920	1481870..1482271	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BBS798_RS24400	1482291..1482527	+	237	WP_003809519.1	hypothetical protein	-
BBS798_RS06925	1482535..1483014	+	480	WP_003809523.1	disulfide bond formation protein B	-
BBS798_RS06930	1483162..1483677	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BBS798_RS06935	1483680..1484870	+	1191	WP_003809527.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BBS798_RS06940	1484890..1485927	+	1038	WP_003809529.1	threonylcarbamoyl-AMP synthase	-
BBS798_RS06945	1486064..1487086	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10608.50 Da
• Isoelectric Point: 7.9291

>T30759 WP_003809515.1 NZ_AP014582:1481571-1481867 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T30759 NZ_AP014582:1481571-1481867 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT30759 WP_003809516.1 NZ_AP014582:1481870-1482271 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT30759 NZ_AP014582:1481870-1482271 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3LPJ8

Antitoxin

• AlphaFold DB: A0A0H3LKS6