Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 58520..59022 Replicon chromosome
Accession NZ_AP014569
Organism Serpentinomonas mccroryi strain B1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A060NKP6
Locus tag SMCB_RS00295 Protein ID WP_045534238.1
Coordinates 58520..58783 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A060NRY4
Locus tag SMCB_RS00300 Protein ID WP_045534240.1
Coordinates 58780..59022 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMCB_RS00285 56083..56796 - 714 WP_045537267.1 DUF4194 domain-containing protein -
SMCB_RS00290 56872..58344 - 1473 WP_045534234.1 DUF3375 domain-containing protein -
SMCB_RS00295 58520..58783 - 264 WP_045534238.1 Txe/YoeB family addiction module toxin Toxin
SMCB_RS00300 58780..59022 - 243 WP_045534240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SMCB_RS00305 59195..59458 + 264 WP_045534241.1 type II toxin-antitoxin system CcdA family antitoxin -
SMCB_RS00310 59368..59775 + 408 WP_082027392.1 CcdB family protein -
SMCB_RS12280 59738..60157 - 420 WP_082027130.1 transglutaminase family protein -
SMCB_RS00320 60218..61561 + 1344 Protein_63 DDE-type integrase/transposase/recombinase -
SMCB_RS00325 61660..62424 + 765 WP_045534247.1 IS21-like element helper ATPase IstB -
SMCB_RS00330 62419..63411 - 993 WP_045534249.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9908.71 Da        Isoelectric Point: 10.6042

>T30683 WP_045534238.1 NZ_AP014569:c58783-58520 [Serpentinomonas mccroryi]
VSWKVVYTKHALKDAQKIAASGLKGKAQALLVLLKDDPFRSPPPLEKLVGDLSGAYSRRINIQHRLVYQVLPESKIVKVL
RMWTHYE

Download         Length: 264 bp

>T30683 NZ_AP014569:c58783-58520 [Serpentinomonas mccroryi]
GTGAGCTGGAAGGTCGTTTACACCAAGCACGCACTCAAAGACGCCCAGAAAATTGCAGCCAGCGGCCTCAAAGGCAAGGC
CCAAGCATTGCTCGTGCTGCTCAAAGACGACCCCTTTCGCAGCCCGCCACCGCTTGAAAAGCTGGTAGGCGATCTGTCGG
GAGCGTATTCGCGGCGCATCAACATTCAACATCGGCTGGTGTACCAAGTGCTGCCAGAGTCCAAAATAGTCAAAGTGTTG
CGCATGTGGACGCACTACGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8894.06 Da        Isoelectric Point: 4.4592

>AT30683 WP_045534240.1 NZ_AP014569:c59022-58780 [Serpentinomonas mccroryi]
MHTLTASQARANLYRLMDQAAESHQPIAITGKHSDAVLISAQDWQAIQETLYLLAVPGMRESIKEGMDQAPEACVQELDW

Download         Length: 243 bp

>AT30683 NZ_AP014569:c59022-58780 [Serpentinomonas mccroryi]
ATGCACACACTCACCGCAAGCCAAGCACGCGCCAACCTGTACCGCCTCATGGATCAGGCAGCCGAGTCGCATCAGCCCAT
CGCCATCACCGGCAAGCACTCTGACGCCGTGCTGATTTCCGCCCAAGACTGGCAGGCCATCCAAGAAACGCTGTACTTGC
TCGCCGTGCCAGGTATGCGTGAGTCCATCAAGGAAGGCATGGATCAGGCCCCAGAGGCCTGCGTCCAGGAGTTGGACTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NKP6

Antitoxin

Source ID Structure
AlphaFold DB A0A060NRY4

References