Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 513718..514535 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name yhaV Uniprot ID A0A060NLJ5
Locus tag SRAA_RS02475 Protein ID WP_045530747.1
Coordinates 513718..514209 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A060NN94
Locus tag SRAA_RS02480 Protein ID WP_045530748.1
Coordinates 514206..514535 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS02450 509426..510376 + 951 WP_045530742.1 hypothetical protein -
SRAA_RS02455 510432..510812 + 381 WP_045530743.1 MbcA/ParS/Xre antitoxin family protein -
SRAA_RS02460 510772..511491 + 720 WP_197538518.1 RES family NAD+ phosphorylase -
SRAA_RS02465 511618..513264 - 1647 WP_045530745.1 chaperonin GroEL -
SRAA_RS02470 513320..513610 - 291 WP_045530746.1 co-chaperone GroES -
SRAA_RS02475 513718..514209 - 492 WP_045530747.1 type II toxin-antitoxin system YhaV family toxin Toxin
SRAA_RS02480 514206..514535 - 330 WP_045530748.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
SRAA_RS02485 514599..515156 - 558 WP_045530749.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
SRAA_RS02490 515269..516453 - 1185 WP_045530750.1 ATP-binding protein -
SRAA_RS02495 516768..517010 + 243 WP_045533140.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SRAA_RS02500 517007..517270 + 264 WP_045530751.1 Txe/YoeB family addiction module toxin -
SRAA_RS02505 517336..517575 + 240 WP_045530752.1 DUF4160 domain-containing protein -
SRAA_RS02510 517547..517804 + 258 WP_045530753.1 DUF2442 domain-containing protein -
SRAA_RS02515 517916..518134 + 219 WP_082040072.1 type II toxin-antitoxin system RelE/ParE family toxin -
SRAA_RS02520 518097..518417 + 321 WP_045530755.1 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18671.35 Da        Isoelectric Point: 10.0417

>T30665 WP_045530747.1 NZ_AP014568:c514209-513718 [Serpentinomonas raichei]
MSAGKPAALVVHGWTVFAHPLFLAQLEVLAQQVEALKQKDPVGYMNKNAAKRLAAVTRLAFDVIPQDPTRPEYRQGNTLG
DDHKHWLRAKFFQQHRLFFRYHATAKAIVLAWVNDEDTKRAYESSDDVYRVFRKMLESGHPPSDWKQLLAEAHAAHTFRT
LPP

Download         Length: 492 bp

>T30665 NZ_AP014568:c514209-513718 [Serpentinomonas raichei]
ATGAGCGCGGGCAAACCTGCCGCACTGGTCGTACACGGCTGGACGGTTTTTGCCCACCCGCTGTTCCTTGCCCAGTTGGA
AGTGCTGGCTCAGCAGGTTGAAGCCTTGAAGCAGAAGGACCCGGTCGGGTACATGAATAAAAACGCCGCCAAGCGACTGG
CGGCGGTCACTAGGCTGGCGTTCGACGTGATCCCGCAAGATCCGACACGACCAGAGTACCGGCAAGGCAACACCCTTGGC
GACGACCACAAGCACTGGTTGCGGGCCAAGTTTTTTCAGCAGCACCGGCTGTTCTTCCGCTACCACGCAACAGCCAAGGC
GATCGTGCTCGCTTGGGTCAACGACGAGGACACCAAGCGCGCCTACGAGAGCAGTGACGACGTCTACCGGGTGTTTCGCA
AGATGCTTGAAAGCGGCCATCCGCCCAGCGACTGGAAGCAATTGCTGGCCGAGGCACACGCCGCCCACACATTTCGCACC
CTCCCCCCTTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12010.56 Da        Isoelectric Point: 4.7025

>AT30665 WP_045530748.1 NZ_AP014568:c514535-514206 [Serpentinomonas raichei]
MAATLEVESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRPGGEVVLSRAEPAQEDDPVLGSFLGLLARDIANHPERLQA
IDAGFVQRLQWLTGGIKVDLDAALSADDE

Download         Length: 330 bp

>AT30665 NZ_AP014568:c514535-514206 [Serpentinomonas raichei]
ATGGCGGCCACCCTTGAAGTCGAATCCACCCTGACCGACCGCTACCAGACCACGGTGCCGGAAACCGTGCGCCGCGCCCT
TCGTCTGGGCAAGCGCGACAAAATCCACTACACCATACGCCCCGGCGGCGAGGTCGTGCTGTCGCGCGCCGAGCCCGCAC
AGGAAGACGACCCGGTGCTGGGATCTTTCCTTGGCTTGTTGGCCCGCGACATCGCCAACCATCCCGAGCGCCTGCAGGCC
ATTGATGCCGGTTTCGTGCAGCGCCTCCAGTGGCTGACTGGCGGCATCAAAGTCGATCTTGACGCGGCCCTGTCGGCAGA
CGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NLJ5

Antitoxin

Source ID Structure
AlphaFold DB A0A060NN94

References