Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 384776..385391 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SRAA_RS01840 Protein ID WP_197538516.1
Coordinates 385059..385391 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SRAA_RS01835 Protein ID WP_045530658.1
Coordinates 384776..385066 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS01810 381476..381769 - 294 WP_045530648.1 type II toxin-antitoxin system RelE/ParE family toxin -
SRAA_RS01815 381766..381990 - 225 WP_045530650.1 addiction module protein -
SRAA_RS01820 382073..382762 - 690 WP_045530652.1 hypothetical protein -
SRAA_RS01825 382996..384087 + 1092 WP_197538515.1 NDP-sugar synthase -
SRAA_RS01830 384115..384714 + 600 WP_045530656.1 lysophospholipid acyltransferase family protein -
SRAA_RS01835 384776..385066 - 291 WP_045530658.1 helix-turn-helix domain-containing protein Antitoxin
SRAA_RS01840 385059..385391 - 333 WP_197538516.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SRAA_RS01845 385520..385744 + 225 WP_082039846.1 hypothetical protein -
SRAA_RS01850 385856..386176 + 321 WP_045530660.1 transcriptional regulator -
SRAA_RS12570 386321..386986 - 666 WP_171820201.1 hypothetical protein -
SRAA_RS01865 387831..389063 + 1233 WP_045530664.1 IS110 family transposase -
SRAA_RS01870 389274..389606 - 333 WP_045533080.1 HigA family addiction module antidote protein -
SRAA_RS12575 389621..389704 - 84 WP_082040069.1 hypothetical protein -
SRAA_RS01875 389920..390198 - 279 WP_045530666.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 381766..390406 8640
- flank IS/Tn - - 387831..389063 1232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(37-102)

Antitoxin

(38-86)


Sequences


Toxin        


Download         Length: 111 a.a.        Molecular weight: 12374.43 Da        Isoelectric Point: 6.9497

>T30663 WP_197538516.1 NZ_AP014568:c385391-385059 [Serpentinomonas raichei]
MEVMVFVELPIFIRCAAELFADEDIAALQNTLLENPAAGDLIPGGRGLRKLRVPLPGRGKRSGARVIYYHWVSKEQCYLI
YAYAKNVSTNLTPVQLRRLAEIMQAEIPDE

Download         Length: 333 bp

>T30663 NZ_AP014568:c385391-385059 [Serpentinomonas raichei]
ATGGAAGTCATGGTTTTTGTGGAACTTCCGATCTTCATCCGCTGTGCAGCCGAACTGTTCGCGGATGAGGATATCGCCGC
GCTGCAGAACACCTTGCTGGAAAATCCCGCCGCTGGCGACTTGATTCCCGGCGGCAGGGGGCTGCGCAAGTTGCGTGTTC
CGTTGCCTGGCAGGGGCAAGCGCAGTGGGGCACGGGTCATCTACTACCACTGGGTGAGCAAGGAGCAGTGCTACTTGATC
TATGCCTATGCGAAAAATGTCAGCACCAATCTGACACCCGTTCAACTGCGGCGGTTGGCCGAGATCATGCAAGCGGAGAT
ACCAGATGAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10831.45 Da        Isoelectric Point: 10.5808

>AT30663 WP_045530658.1 NZ_AP014568:c385066-384776 [Serpentinomonas raichei]
MNDQQFDELLDSVRDMGRHMRGEKLLGVRVQAFPEPDVKAIRERTGLSQSRFAHLIGVKPKTLQNWEQHRVRPAGPARAL
LKIVEANPDALSALHA

Download         Length: 291 bp

>AT30663 NZ_AP014568:c385066-384776 [Serpentinomonas raichei]
ATGAATGACCAACAGTTCGACGAGTTGCTCGACAGCGTGCGCGACATGGGGCGCCATATGCGCGGCGAGAAGCTGCTGGG
CGTTCGCGTGCAGGCGTTTCCTGAGCCCGATGTCAAGGCGATCCGTGAGCGCACCGGTCTGTCGCAGAGTCGTTTCGCCC
ACCTGATCGGCGTCAAGCCCAAGACCCTGCAGAACTGGGAGCAACATCGCGTGCGTCCAGCAGGACCTGCGCGCGCCTTG
CTAAAGATCGTCGAAGCCAACCCTGATGCGCTCTCGGCGCTTCACGCATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References