Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 425770..426403 | Replicon | chromosome |
| Accession | NZ_AP014525 | ||
| Organism | Vibrio cholerae MS6 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | MS6_RS15785 | Protein ID | WP_000843587.1 |
| Coordinates | 425770..426102 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MS6_RS15790 | Protein ID | WP_000071008.1 |
| Coordinates | 426089..426403 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MS6_RS20425 | 420912..421115 | + | 204 | WP_001911745.1 | hypothetical protein | - |
| MS6_RS20235 | 421396..421569 | + | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
| MS6_RS15760 | 421929..422198 | + | 270 | WP_001198131.1 | hypothetical protein | - |
| MS6_RS20495 | 422516..422687 | + | 172 | Protein_453 | DUF645 family protein | - |
| MS6_RS15765 | 422935..423312 | + | 378 | WP_000411109.1 | hypothetical protein | - |
| MS6_RS20440 | 423369..423483 | + | 115 | Protein_455 | acetyltransferase | - |
| MS6_RS19740 | 423432..423686 | + | 255 | WP_080314586.1 | DUF1289 domain-containing protein | - |
| MS6_RS15775 | 423729..424906 | + | 1178 | WP_086010879.1 | IS3-like element ISVch4 family transposase | - |
| MS6_RS19755 | 425140..425253 | + | 114 | WP_001889158.1 | hypothetical protein | - |
| MS6_RS19760 | 425202..425429 | + | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| MS6_RS15785 | 425770..426102 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MS6_RS15790 | 426089..426403 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| MS6_RS15795 | 426540..426974 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| MS6_RS20445 | 427142..427297 | + | 156 | WP_000751734.1 | hypothetical protein | - |
| MS6_RS15805 | 427422..428402 | - | 981 | WP_041051966.1 | IS5-like element ISVch5 family transposase | - |
| MS6_RS15810 | 428470..428776 | + | 307 | Protein_465 | CatB-related O-acetyltransferase | - |
| MS6_RS15815 | 428913..429605 | + | 693 | WP_001047177.1 | GNAT family N-acetyltransferase | - |
| MS6_RS15820 | 429605..430006 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| MS6_RS20245 | 429976..430119 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| MS6_RS15825 | 430194..430607 | + | 414 | WP_000049417.1 | VOC family protein | - |
| MS6_RS15830 | 430821..431072 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MS6_RS15835 | 431062..431349 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 297729..445581 | 147852 | |
| - | inside | Integron | qnrVC4 | - | 302809..445205 | 142396 | |
| - | inside | IScluster/Tn | - | - | 423729..428402 | 4673 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T30644 WP_000843587.1 NZ_AP014525:425770-426102 [Vibrio cholerae MS6]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T30644 NZ_AP014525:425770-426102 [Vibrio cholerae MS6]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT30644 WP_000071008.1 NZ_AP014525:426089-426403 [Vibrio cholerae MS6]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT30644 NZ_AP014525:426089-426403 [Vibrio cholerae MS6]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|