30633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1123063..1123651 Replicon chromosome
Accession NZ_AP014523
Organism Helicobacter pylori NY40

Toxin (Protein)


Gene name TfiT Uniprot ID A0A060Q148
Locus tag NY40_RS05580 Protein ID WP_041051062.1
Coordinates 1123063..1123344 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID M3MZZ5
Locus tag NY40_RS05585 Protein ID WP_001941297.1
Coordinates 1123337..1123651 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY40_RS05545 1118272..1118535 + 264 WP_041051049.1 hypothetical protein -
NY40_RS05550 1118532..1118831 + 300 WP_041051051.1 hypothetical protein -
NY40_RS05555 1118831..1119772 + 942 WP_041051053.1 Flp pilus assembly complex ATPase component TadA -
NY40_RS05560 1119769..1120224 + 456 WP_041051056.1 hypothetical protein -
NY40_RS05565 1120221..1120511 + 291 WP_000159810.1 hypothetical protein -
NY40_RS05570 1120512..1121069 + 558 WP_041051058.1 hypothetical protein -
NY40_RS05575 1121070..1122797 + 1728 WP_041051060.1 type IV secretory system conjugative DNA transfer family protein -
NY40_RS05580 1123063..1123344 - 282 WP_041051062.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
NY40_RS05585 1123337..1123651 - 315 WP_001941297.1 hypothetical protein Antitoxin
NY40_RS05590 1123946..1125859 + 1914 WP_041051066.1 relaxase/mobilization nuclease domain-containing protein -
NY40_RS05595 1125885..1127063 - 1179 WP_041051068.1 hypothetical protein -
NY40_RS05600 1127107..1127391 - 285 WP_000394639.1 hypothetical protein -
NY40_RS05605 1127473..1128129 - 657 WP_041051070.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10862.76 Da        Isoelectric Point: 9.1812

>T30633 WP_041051062.1 NZ_AP014523:c1123344-1123063 [Helicobacter pylori NY40]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKEQKPLQQKYCDHALSGDLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T30633 NZ_AP014523:c1123344-1123063 [Helicobacter pylori NY40]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTGCAAGCGTTGTTGATTGTCTAAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCGATC
TTAAAGGGCTGAGAGAATGCCATGTCAAACCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12207.65 Da        Isoelectric Point: 5.2068

>AT30633 WP_001941297.1 NZ_AP014523:c1123651-1123337 [Helicobacter pylori NY40]
MPNVITDYSQYNEKQLQHFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT30633 NZ_AP014523:c1123651-1123337 [Helicobacter pylori NY40]
ATGCCAAATGTTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCAACATTTTTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAGG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACGCAAAGCCTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTGCAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060Q148

Antitoxin

Source ID Structure
AlphaFold DB M3MZZ5

References