Detailed information of TA system TA030602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2097878..2098391
• Replicon: chromosome
• Accession: NZ_AP013072
• Organism: Streptococcus anginosus subsp. whileyi MAS624

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: I0SIM6
• Locus tag: ANG_RS10435
• Protein ID: WP_003034719.1
• Coordinates: 2098137..2098391 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I0SIL5
• Locus tag: ANG_RS10430
• Protein ID: WP_003034688.1
• Coordinates: 2097878..2098144 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ANG_RS10390	2092878..2093240	-	363	WP_003034723.1	helix-turn-helix domain-containing protein	-
ANG_RS10395	2093913..2094185	+	273	WP_003034600.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
ANG_RS10400	2094186..2094464	+	279	WP_003034637.1	type II toxin-antitoxin system YafQ family toxin	-
ANG_RS10405	2094593..2094829	+	237	WP_003034655.1	hypothetical protein	-
ANG_RS10410	2094860..2095087	+	228	WP_003034721.1	hypothetical protein	-
ANG_RS10415	2095202..2095516	+	315	WP_000406626.1	hypothetical protein	-
ANG_RS10420	2095539..2095949	+	411	WP_003034661.1	DUF961 family protein	-
ANG_RS10425	2095956..2097614	+	1659	WP_003034653.1	cell division protein FtsK	-
ANG_RS10430	2097878..2098144	+	267	WP_003034688.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ANG_RS10435	2098137..2098391	+	255	WP_003034719.1	Txe/YoeB family addiction module toxin	Toxin
ANG_RS10440	2098445..2099677	+	1233	WP_025272020.1	replication initiation factor domain-containing protein	-
ANG_RS10445	2099655..2100041	+	387	WP_003034694.1	hypothetical protein	-
ANG_RS10450	2100061..2100297	+	237	WP_000456039.1	hypothetical protein	-
ANG_RS10455	2100294..2100848	+	555	WP_003034624.1	hypothetical protein	-
ANG_RS10460	2100858..2101850	+	993	WP_003034679.1	conjugal transfer protein	-
ANG_RS10465	2101867..2102094	+	228	WP_002271001.1	hypothetical protein	-
ANG_RS10470	2102096..2102512	+	417	WP_020999431.1	conjugal transfer protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2087414..2109746	22332

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10509.97 Da
• Isoelectric Point: 9.2761

>T30602 WP_003034719.1 NZ_AP013072:2098137-2098391 [Streptococcus anginosus subsp. whileyi MAS624]
MFNFTEQAWKDYVSWQQEDKKILKRINRLMEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEHRLVYMVEENEIYFLSFR
DHYK

Nucleotide

• Length: 255 bp

>T30602 NZ_AP013072:2098137-2098391 [Streptococcus anginosus subsp. whileyi MAS624]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAAGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATGGAGGATATCAAACGAAATCCTTTTGAAGGGATTGGAAAGCCTGAACCCTTAAAATACCGTTATTCCGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGATTAGTCTATATGGTGGAAGAAAATGAGATTTATTTCTTATCCTTTCGA
GACCACTATAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10405.92 Da
• Isoelectric Point: 4.6437

>AT30602 WP_003034688.1 NZ_AP013072:2097878-2098144 [Streptococcus anginosus subsp. whileyi MAS624]
MEAVVYSNFRNNLKNYMKKVNDEYEPLMVVNKNPDENIVVLSKENWDSIQETIRLMNNDYLSDKVLSGMEQVKQKKVIQR
PLLEVEDV

Nucleotide

• Length: 267 bp

>AT30602 NZ_AP013072:2097878-2098144 [Streptococcus anginosus subsp. whileyi MAS624]
ATGGAAGCTGTCGTCTATTCAAATTTTAGAAACAATTTAAAGAATTACATGAAAAAAGTCAACGATGAATATGAACCTCT
AATGGTTGTCAATAAAAATCCTGATGAAAATATTGTGGTCTTATCTAAGGAAAACTGGGATAGTATTCAAGAAACCATTC
GCCTAATGAATAATGATTATCTTTCAGACAAGGTTCTATCAGGAATGGAACAAGTCAAGCAAAAGAAAGTCATTCAACGC
CCATTATTAGAGGTGGAAGATGTTTAA

Structures

Toxin

• AlphaFold DB: I0SIM6

Antitoxin

• AlphaFold DB: I0SIL5