Detailed information of TA system TA030593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3552063..3552715
• Replicon: chromosome
• Accession: NZ_AP013063
• Organism: Serratia marcescens SM39

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: SM39_RS16590
• Protein ID: WP_041036518.1
• Coordinates: 3552063..3552407 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A086GAN0
• Locus tag: SM39_RS16595
• Protein ID: WP_004931828.1
• Coordinates: 3552413..3552715 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM39_RS16575	3548406..3550664	-	2259	WP_041036515.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
SM39_RS16585	3550885..3551904	+	1020	WP_033649496.1	HTH-type transcriptional regulator GalR	-
SM39_RS16590	3552063..3552407	+	345	WP_041036518.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SM39_RS16595	3552413..3552715	+	303	WP_004931828.1	helix-turn-helix transcriptional regulator	Antitoxin
SM39_RS16600	3552743..3554005	-	1263	WP_033649495.1	diaminopimelate decarboxylase	-
SM39_RS16605	3554139..3555062	+	924	WP_041036520.1	LysR family transcriptional regulator	-
SM39_RS16610	3555090..3555998	-	909	WP_041036522.1	LysR family transcriptional regulator	-
SM39_RS16615	3556107..3556991	+	885	WP_041036524.1	MBL fold metallo-hydrolase	-
SM39_RS16620	3557060..3557707	+	648	WP_039567349.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-85)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13425.48 Da
• Isoelectric Point: 10.4277

>T30593 WP_041036518.1 NZ_AP013063:3552063-3552407 [Serratia marcescens SM39]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T30593 NZ_AP013063:3552063-3552407 [Serratia marcescens SM39]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTACAAATTGCAGACGTTCGGCCCGCAGTTGACGCGGCCGCATGCCGATACGCTGTATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCGTTCAACACCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11080.97 Da
• Isoelectric Point: 10.1998

>AT30593 WP_004931828.1 NZ_AP013063:3552413-3552715 [Serratia marcescens SM39]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT30593 NZ_AP013063:3552413-3552715 [Serratia marcescens SM39]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAACTGTCATCGCTCAAACGCTATATCGAGGCCATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A086GAN0