Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2787986..2788646 Replicon chromosome
Accession NZ_AP013063
Organism Serratia marcescens SM39

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BYZ0
Locus tag SM39_RS13140 Protein ID WP_041035904.1
Coordinates 2788293..2788646 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag SM39_RS13135 Protein ID WP_033635213.1
Coordinates 2787986..2788288 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM39_RS13115 2783608..2784522 - 915 WP_041035900.1 branched-chain amino acid ABC transporter permease -
SM39_RS13120 2784648..2785766 - 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
SM39_RS13130 2786370..2787578 - 1209 WP_041035902.1 aldose 1-epimerase family protein -
SM39_RS13135 2787986..2788288 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
SM39_RS13140 2788293..2788646 - 354 WP_041035904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SM39_RS13145 2789086..2790381 + 1296 WP_041035906.1 MFS transporter -
SM39_RS13150 2790409..2791215 + 807 WP_041035908.1 substrate-binding domain-containing protein -
SM39_RS13155 2791190..2792089 - 900 WP_039565149.1 LysR family transcriptional regulator -
SM39_RS13160 2792182..2792547 - 366 WP_033635218.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13446.27 Da        Isoelectric Point: 8.9000

>T30591 WP_041035904.1 NZ_AP013063:c2788646-2788293 [Serratia marcescens SM39]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

>T30591 NZ_AP013063:c2788646-2788293 [Serratia marcescens SM39]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCGGATGATTCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT30591 WP_033635213.1 NZ_AP013063:c2788288-2787986 [Serratia marcescens SM39]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT30591 NZ_AP013063:c2788288-2787986 [Serratia marcescens SM39]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCTGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTCAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCAGACGGCTCTCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BYZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References