Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 620098..620714 Replicon chromosome
Accession NZ_AP013043
Organism Isorropodon fossajaponicum endosymbiont JTNG4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CVFO_RS03690 Protein ID WP_201340234.1
Coordinates 620385..620714 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CVFO_RS03685 Protein ID WP_201340397.1
Coordinates 620098..620385 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVFO_RS03625 615163..615411 + 249 WP_201340223.1 hypothetical protein -
CVFO_RS03630 615518..615928 + 411 WP_201340224.1 hypothetical protein -
CVFO_RS03635 616153..616404 + 252 WP_201340225.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CVFO_RS03640 616394..616677 + 284 Protein_703 type II toxin-antitoxin system RelE/ParE family toxin -
CVFO_RS03645 616999..617244 + 246 WP_201340226.1 hypothetical protein -
CVFO_RS03650 617241..617675 + 435 WP_201340227.1 hypothetical protein -
CVFO_RS03655 617668..618393 + 726 WP_201340228.1 hypothetical protein -
CVFO_RS03660 618386..618679 + 294 WP_201340229.1 hypothetical protein -
CVFO_RS03665 618747..618929 + 183 WP_201340230.1 type II toxin-antitoxin system HicA family toxin -
CVFO_RS03670 618929..619315 + 387 WP_201340231.1 type II toxin-antitoxin system HicB family antitoxin -
CVFO_RS03675 619448..619687 + 240 WP_201340232.1 type II toxin-antitoxin system RelE/ParE family toxin -
CVFO_RS03680 619698..620063 + 366 WP_201340233.1 helix-turn-helix domain-containing protein -
CVFO_RS03685 620098..620385 - 288 WP_201340397.1 helix-turn-helix transcriptional regulator Antitoxin
CVFO_RS03690 620385..620714 - 330 WP_201340234.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CVFO_RS03695 621056..621358 + 303 WP_201340235.1 DUF2786 domain-containing protein -
CVFO_RS03700 622227..622928 - 702 WP_201340236.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
CVFO_RS03705 622994..623629 + 636 WP_201340237.1 HAD-IA family hydrolase -
CVFO_RS03710 623671..624765 + 1095 WP_201340398.1 DNA recombination protein RmuC -
CVFO_RS03715 624765..625517 + 753 WP_201340238.1 YciK family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-89)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12480.75 Da        Isoelectric Point: 10.6572

>T30578 WP_201340234.1 NZ_AP013043:c620714-620385 [Isorropodon fossajaponicum endosymbiont JTNG4]
MSYKISYFNDAVQNDILNLPASLSLLARYLKSTDMMLIHGSNLGHPHTKSLSNGLFELRLKGKNGIARVFYCTQTNQEII
MLHSYVKKSKKIPRNVLQIALTRLKEMKK

Download         Length: 330 bp

>T30578 NZ_AP013043:c620714-620385 [Isorropodon fossajaponicum endosymbiont JTNG4]
ATGAGTTATAAGATAAGTTATTTTAATGATGCGGTGCAAAATGATATTTTAAATTTACCAGCGTCTCTGTCTCTGTTAGC
TAGATATTTGAAGTCTACAGATATGATGTTAATTCATGGTTCAAATTTAGGACACCCACACACCAAATCATTAAGTAACG
GATTGTTTGAATTGAGATTAAAAGGCAAGAATGGGATAGCAAGAGTTTTTTATTGCACCCAAACAAATCAAGAAATTATT
ATGCTACATTCTTATGTAAAAAAATCTAAAAAAATACCTAGAAATGTTTTGCAAATTGCGCTAACCAGATTAAAGGAGAT
GAAAAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10546.13 Da        Isoelectric Point: 9.9392

>AT30578 WP_201340397.1 NZ_AP013043:c620385-620098 [Isorropodon fossajaponicum endosymbiont JTNG4]
MTHKQLKQKALSNASVKKEYDDLSLEFSLLNQMLSARKNIGLSQTEVAERMGTKQTAITRLESSLASGKLSPSLATINKY
ANAVDCDIDIKFIQR

Download         Length: 288 bp

>AT30578 NZ_AP013043:c620385-620098 [Isorropodon fossajaponicum endosymbiont JTNG4]
ATGACACACAAACAACTAAAACAAAAAGCACTTTCTAATGCCAGTGTTAAAAAAGAATATGACGATCTATCTCTAGAATT
TAGTTTACTTAACCAAATGCTATCAGCCAGAAAAAATATTGGACTTAGTCAAACTGAAGTCGCTGAAAGAATGGGAACAA
AACAAACAGCAATTACTAGACTTGAATCCTCTCTTGCAAGTGGCAAACTATCACCATCTCTTGCAACAATCAACAAGTAC
GCCAATGCGGTTGATTGCGATATTGACATTAAATTTATTCAAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References