Detailed information of TA system TA030570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 3670340..3670976
• Replicon: chromosome
• Accession: NZ_AP012547
• Organism: Sulfuritalea hydrogenivorans sk43H strain DSM 22779

Toxin (Protein)

• Gene name: higB
• Uniprot ID: W0SN76
• Locus tag: SUTH_RS17430
• Protein ID: WP_041101073.1
• Coordinates: 3670340..3670666 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SUTH_RS17435
• Protein ID: WP_041101075.1
• Coordinates: 3670659..3670976 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUTH_RS17400	3665612..3666088	-	477	WP_084207493.1	acyl-CoA thioesterase	-
SUTH_RS17405	3666154..3666339	-	186	WP_197539617.1	hypothetical protein	-
SUTH_RS17410	3666431..3667708	-	1278	WP_041101067.1	AmpG family muropeptide MFS transporter	-
SUTH_RS17415	3667773..3668072	-	300	WP_041101069.1	putative addiction module antidote protein	-
SUTH_RS17420	3668227..3669093	-	867	WP_041101071.1	integron integrase	-
SUTH_RS19180	3669536..3669943	+	408	WP_171817403.1	hypothetical protein	-
SUTH_RS19760	3670016..3670189	-	174	WP_041102560.1	hypothetical protein	-
SUTH_RS17430	3670340..3670666	+	327	WP_041101073.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SUTH_RS17435	3670659..3670976	+	318	WP_041101075.1	helix-turn-helix domain-containing protein	Antitoxin
SUTH_RS17440	3670973..3671155	+	183	WP_041101077.1	hypothetical protein	-
SUTH_RS17445	3671184..3671498	+	315	WP_197539618.1	DUF1330 domain-containing protein	-
SUTH_RS19765	3671612..3671782	+	171	WP_171817404.1	hypothetical protein	-
SUTH_RS17450	3671805..3672398	-	594	WP_041101079.1	methionine biosynthesis protein MetW	-
SUTH_RS17455	3672395..3673513	-	1119	WP_041101080.1	homoserine O-acetyltransferase	-
SUTH_RS17460	3673692..3675431	-	1740	WP_041101081.1	phosphoenolpyruvate--protein phosphotransferase	-
SUTH_RS17465	3675428..3675697	-	270	WP_041101082.1	HPr family phosphocarrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-95)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12521.51 Da
• Isoelectric Point: 9.5971

>T30570 WP_041101073.1 NZ_AP012547:3670340-3670666 [Sulfuritalea hydrogenivorans sk43H]
MSFEIEYFHERVLHDVESWPVDVLADYARLVELLIEHGPSLRLPHSRAFGDGLFELRPRGRSGIGRAFYCFLVGKRVVVL
HAFIKKSQETPDRELKLARKRMKEVSNG

Nucleotide

• Length: 327 bp

>T30570 NZ_AP012547:3670340-3670666 [Sulfuritalea hydrogenivorans sk43H]
ATGTCTTTCGAGATCGAGTACTTCCACGAGCGGGTGCTTCACGACGTTGAGTCGTGGCCTGTGGACGTCCTAGCCGACTA
CGCACGCTTGGTTGAACTGCTAATCGAACACGGACCGAGTCTCAGGCTCCCGCACTCGCGAGCCTTTGGTGACGGCTTGT
TTGAGCTTCGGCCTCGCGGTCGTTCCGGCATTGGTCGAGCGTTCTACTGCTTTCTCGTTGGCAAACGGGTTGTCGTCCTG
CACGCCTTCATAAAGAAGTCTCAGGAAACACCCGACCGAGAATTGAAGTTAGCGCGAAAGCGCATGAAGGAGGTTTCAAA
TGGCTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11471.34 Da
• Isoelectric Point: 10.8462

>AT30570 WP_041101075.1 NZ_AP012547:3670659-3670976 [Sulfuritalea hydrogenivorans sk43H]
MAELKFKPVRHSHKEFLAKAATRKGFVEAYDALALEYQVAGQMLKARSRAGLTQDAVAERMGTTKSAVSRLESAGKHAPS
LATLKRYAQAVGCELQVKLVRQRAA

Nucleotide

• Length: 318 bp

>AT30570 NZ_AP012547:3670659-3670976 [Sulfuritalea hydrogenivorans sk43H]
ATGGCTGAACTGAAATTCAAACCCGTCCGCCATTCGCACAAGGAGTTTCTTGCGAAGGCAGCAACCCGCAAGGGGTTCGT
CGAAGCCTATGACGCCCTTGCTCTTGAGTACCAGGTTGCCGGCCAAATGCTCAAGGCGCGTTCTCGTGCCGGCCTGACGC
AAGACGCCGTTGCTGAACGAATGGGAACAACCAAAAGCGCGGTTTCGAGGCTCGAATCTGCTGGAAAGCATGCCCCGTCG
CTCGCAACGCTCAAACGGTATGCGCAAGCTGTCGGTTGTGAACTTCAAGTAAAGCTCGTACGGCAGAGGGCGGCATGA

Structures

Toxin

• AlphaFold DB: W0SN76