Detailed information of TA system TA030568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 2250412..2250914
• Replicon: chromosome
• Accession: NZ_AP012547
• Organism: Sulfuritalea hydrogenivorans sk43H strain DSM 22779

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SUTH_RS10840
• Protein ID: WP_197539710.1
• Coordinates: 2250684..2250914 (+)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: W0SFD4
• Locus tag: SUTH_RS10835
• Protein ID: WP_041099200.1
• Coordinates: 2250412..2250654 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUTH_RS10805	2245836..2246510	+	675	WP_084207564.1	fused MFS/spermidine synthase	-
SUTH_RS10810	2246518..2247444	+	927	WP_041099192.1	DMT family transporter	-
SUTH_RS10820	2248517..2248987	-	471	WP_171817356.1	transposase	-
SUTH_RS10825	2249599..2249883	+	285	WP_041099196.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
SUTH_RS10830	2249885..2250145	+	261	WP_041099198.1	helix-turn-helix domain-containing protein	-
SUTH_RS10835	2250412..2250654	+	243	WP_041099200.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SUTH_RS10840	2250684..2250914	+	231	WP_197539710.1	Txe/YoeB family addiction module toxin	Toxin
SUTH_RS10845	2251019..2251996	-	978	WP_052473843.1	beta-N-acetylhexosaminidase	-
SUTH_RS10850	2252020..2252397	-	378	WP_041099203.1	holo-ACP synthase	-
SUTH_RS10855	2252394..2253143	-	750	WP_041099205.1	pyridoxine 5'-phosphate synthase	-
SUTH_RS10860	2253310..2254026	-	717	WP_041099207.1	DNA repair protein RecO	-
SUTH_RS10865	2254031..2254918	-	888	WP_041099209.1	GTPase Era	-
SUTH_RS10870	2254915..2255583	-	669	WP_041099211.1	ribonuclease III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (14-75)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 8798.34 Da
• Isoelectric Point: 10.1386

>T30568 WP_197539710.1 NZ_AP012547:2250684-2250914 [Sulfuritalea hydrogenivorans sk43H]
MKDAKKLAACGLKQKAQELLAILADDPFRNPPPFEKLVGDLAGAYSRRINIQHRIVYEVFAKEKTVRVLRMWTHYE

Nucleotide

• Length: 231 bp

>T30568 NZ_AP012547:2250684-2250914 [Sulfuritalea hydrogenivorans sk43H]
ATGAAGGACGCAAAGAAGCTTGCTGCATGTGGTCTTAAACAAAAGGCACAAGAACTGCTCGCGATTCTTGCCGACGACCC
ATTTCGAAATCCACCACCCTTCGAAAAGTTGGTCGGCGATCTTGCTGGCGCGTACTCTCGCCGCATCAATATTCAGCACC
GCATTGTGTACGAGGTCTTTGCCAAAGAGAAAACGGTTCGTGTCCTGCGTATGTGGACTCACTATGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8774.08 Da
• Isoelectric Point: 7.0095

>AT30568 WP_041099200.1 NZ_AP012547:2250412-2250654 [Sulfuritalea hydrogenivorans sk43H]
MNTLTASEARANLYRLIDQTAESHEPITISGKRSNAVLLSAEDWSAIQETLYLLAVPGMRESIKAGMAEPLAKSSKVLKW

Nucleotide

• Length: 243 bp

>AT30568 NZ_AP012547:2250412-2250654 [Sulfuritalea hydrogenivorans sk43H]
ATGAACACGCTTACCGCCAGCGAAGCTCGCGCAAACCTGTACAGACTCATTGATCAAACAGCCGAGTCTCATGAGCCAAT
CACCATTTCCGGAAAACGCAGCAATGCCGTGCTGCTATCCGCAGAAGATTGGAGCGCAATTCAGGAAACCTTGTACCTAC
TGGCCGTGCCTGGCATGCGCGAGTCCATCAAAGCTGGCATGGCCGAGCCCCTCGCAAAAAGTTCGAAGGTGCTTAAGTGG
TGA

Structures

Antitoxin

• AlphaFold DB: W0SFD4