Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1631216..1631794 Replicon chromosome
Accession NZ_AP012273
Organism Thiolapillus brandeum strain Hiromi

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TBH_RS15215 Protein ID WP_082030810.1
Coordinates 1631537..1631794 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TBH_RS07745 Protein ID WP_172649480.1
Coordinates 1631216..1631527 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBH_RS07725 1626794..1627009 + 216 WP_041067207.1 hypothetical protein -
TBH_RS07735 1629991..1630293 - 303 WP_041067213.1 type I-E CRISPR-associated endoribonuclease Cas2 -
TBH_RS07740 1630296..1631210 - 915 WP_041067216.1 type I-E CRISPR-associated endonuclease Cas1 -
TBH_RS07745 1631216..1631527 - 312 WP_172649480.1 HigA family addiction module antidote protein Antitoxin
TBH_RS15215 1631537..1631794 - 258 WP_082030810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBH_RS15220 1632019..1632705 - 687 WP_082030654.1 type I-E CRISPR-associated protein Cas6/Cse3/CasE -
TBH_RS07765 1632702..1633406 - 705 WP_041070580.1 type I-E CRISPR-associated protein Cas5/CasD -
TBH_RS07770 1633409..1634443 - 1035 WP_041067220.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
TBH_RS15225 1634466..1635002 - 537 WP_052469988.1 type I-E CRISPR-associated protein Cse2/CasB -
TBH_RS07780 1635017..1636594 - 1578 WP_041067223.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(38-85)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(13-96)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9960.35 Da        Isoelectric Point: 8.3106

>T30536 WP_082030810.1 NZ_AP012273:c1631794-1631537 [Thiolapillus brandeum]
MCGHFQWPSVIENGGKTKSHFCLSELKKPMEGLFQHPVKVPPGNRLEPLQGNRAGQWSIRINDQWRICFRWDRGHAFDVE
ITDYH

Download         Length: 258 bp

>T30536 NZ_AP012273:c1631794-1631537 [Thiolapillus brandeum]
ATGTGCGGCCATTTTCAATGGCCATCAGTCATTGAAAATGGAGGAAAGACAAAATCACATTTTTGTCTTTCCGAGTTGAA
AAAGCCCATGGAAGGGCTTTTTCAACATCCTGTTAAAGTTCCGCCCGGCAATCGCCTGGAGCCACTCCAGGGCAACCGGG
CGGGACAGTGGAGCATCCGCATCAACGATCAATGGCGGATTTGTTTTCGCTGGGATAGAGGTCACGCCTTCGACGTGGAG
ATCACCGACTATCATTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11769.52 Da        Isoelectric Point: 10.5322

>AT30536 WP_172649480.1 NZ_AP012273:c1631527-1631216 [Thiolapillus brandeum]
MNKPDNNDLLPLSTPGDILRREFMEPLGLSANALARALHVPPNRISIILQGKRAISADTALRLARYFETSAEFWLNLQTD
YDLRQARREKDATIRREVKPRVA

Download         Length: 312 bp

>AT30536 NZ_AP012273:c1631527-1631216 [Thiolapillus brandeum]
ATGAATAAACCGGACAACAACGACCTGCTTCCCCTGAGCACACCGGGTGATATTCTGCGTCGGGAGTTCATGGAACCGCT
GGGGCTGTCGGCCAACGCCCTGGCACGCGCTCTGCACGTTCCGCCCAACCGTATCAGCATCATTCTACAAGGCAAACGTG
CCATTTCTGCCGATACCGCACTGCGTCTGGCGCGCTATTTTGAAACCAGTGCGGAGTTTTGGCTCAATCTGCAAACCGAT
TATGACCTGCGACAAGCGCGGCGGGAGAAGGATGCCACCATCCGCCGAGAGGTCAAACCCCGCGTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References