30446

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1482039..1482487 Replicon chromosome
Accession NC_023151
Organism Thermotoga maritima MSB8

Toxin (Protein)


Gene name hicA Uniprot ID Q9X138
Locus tag THEMA_RS07700 Protein ID WP_004079902.1
Coordinates 1482254..1482487 (+) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID G4FE38
Locus tag THEMA_RS07695 Protein ID WP_004079900.1
Coordinates 1482039..1482257 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THEMA_RS07675 1478310..1479701 - 1392 WP_004083362.1 radical SAM protein -
THEMA_RS07680 1479803..1479898 - 96 WP_010865309.1 Cys-rich RiPP peptide -
THEMA_RS07685 1479975..1480139 - 165 WP_004083364.1 hypothetical protein -
THEMA_RS07690 1480335..1481942 + 1608 WP_010865307.1 helix-turn-helix domain-containing protein -
THEMA_RS07695 1482039..1482257 + 219 WP_004079900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
THEMA_RS07700 1482254..1482487 + 234 WP_004079902.1 type II toxin-antitoxin system HicA family toxin Toxin
THEMA_RS07705 1482510..1482722 + 213 WP_004079908.1 hypothetical protein -
THEMA_RS09750 1482712..1482861 + 150 WP_081434644.1 type II toxin-antitoxin system HicA family toxin -
THEMA_RS07710 1482932..1484674 - 1743 WP_004079909.1 ABC transporter ATP-binding protein/permease -
THEMA_RS09850 1484737..1485507 - 771 Protein_1484 ABC transporter permease -
THEMA_RS07725 1485511..1485945 - 435 WP_004079914.1 ABC transporter permease -
THEMA_RS07735 1486163..1486969 - 807 WP_004079915.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1479975..1490201 10226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-56)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8983.60 Da        Isoelectric Point: 10.4691

>T30446 WP_004079902.1 NC_023151:1482254-1482487 [Thermotoga maritima MSB8]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGKYTTIPFHAKETCPSHLIRKIIREAGISVEEFKKVLENL

Download         Length: 234 bp

>T30446 NC_023151:1482254-1482487 [Thermotoga maritima MSB8]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGAAAGTATACGACCATCCCATTTCATGCAAAAGAGACTTGCCCAAGTC
ACTTAATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8186.38 Da        Isoelectric Point: 4.0891

>AT30446 WP_004079900.1 NC_023151:1482039-1482257 [Thermotoga maritima MSB8]
VRKIFTAIIEYDPEKKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINLQEFVALEMIEVET

Download         Length: 219 bp

>AT30446 NC_023151:1482039-1482257 [Thermotoga maritima MSB8]
GTGCGTAAAATTTTCACAGCTATCATTGAATACGATCCTGAAAAAAAGCAATATGTTGGAATGGTTCCAGATGTTCCAGG
TGTACATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCTCCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9X138

Antitoxin

Source ID Structure
AlphaFold DB G4FE38

References