Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1496994..1497639 Replicon chromosome
Accession NC_023032
Organism Cronobacter sakazakii CMCC 45402

Toxin (Protein)


Gene name higB Uniprot ID A0A423Y0Z1
Locus tag P262_RS07060 Protein ID WP_007776379.1
Coordinates 1496994..1497356 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A423Y0X2
Locus tag P262_RS07065 Protein ID WP_007776376.1
Coordinates 1497343..1497639 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P262_RS07050 1492395..1495517 - 3123 WP_023898424.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -
P262_RS07055 1495517..1496764 - 1248 WP_023898425.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
P262_RS07060 1496994..1497356 + 363 WP_007776379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P262_RS07065 1497343..1497639 + 297 WP_007776376.1 XRE family transcriptional regulator Antitoxin
P262_RS07070 1497649..1499001 - 1353 WP_023898428.1 molecular chaperone -
P262_RS07075 1499137..1499985 + 849 WP_007776367.1 DNA-3-methyladenine glycosylase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14303.20 Da        Isoelectric Point: 8.0081

>T30383 WP_007776379.1 NC_023032:1496994-1497356 [Cronobacter malonaticus]
MTWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENY

Download         Length: 363 bp

>T30383 NC_023032:1496994-1497356 [Cronobacter malonaticus]
ATGACATGGACGGTGATTTTTACCGATCGTTTTAACGACTGGTATCAACAGCAGCCCGAAGGATTACAGGATCGTATCGC
TGCGCTCTTATGGAACTTGCGTTATTCCGGCCCGCTTGTCGGACGCCCGCTGGTCGATACGGTCAAAGGTTCGCGTTATC
CCAACCTGAAAGAGCTGCGTGTGCAGTATGGCGGCGAACCCTGGCGCGTCTTTTTTGCGTTTGACGCTGAACGTCAGGCC
GTTGTGCTCTGTGCAGGCAATAAGCGCAGCCAGAAACATTTTTATGACGCCCTAATCAGGCAGGCTGAAGAAGAATTCTT
CCTGCATGTGCAAGCAATGGAGAGACGAAATGAAAACTATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT30383 WP_007776376.1 NC_023032:1497343-1497639 [Cronobacter malonaticus]
MKTIDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT30383 NC_023032:1497343-1497639 [Cronobacter malonaticus]
ATGAAAACTATTGATGACGTAATGGCGGGCTTTTCCCCGGAACGGCAGGCTGAAATCCTGCGCATGGCTGACGAAATCGC
GCTGGAACACGGCCTGCCGCGCATTCGCGAAGCGCGGGCGTTTTCGCAGCAGCAGCTGGCGGAGATAATGGGCGTGACGC
AGCCCGCTATCGCCGCCATTGAGCAGCGCGGCAAGGAGATCAAACTGCTGACGCTCAAGCGCTATGTCGAAGCGCTGGGC
GGCAAGCTCTCTTTGCTGATAGAGCTGCCCGAAGGCAGCAAAGTGATCCCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A423Y0Z1

Antitoxin

Source ID Structure
AlphaFold DB A0A423Y0X2

References